Mount Sinai researchers have developed a bank of induced pluripotent stem cells from healthy people

Scientists at Mount Sinai have created a good library of human induced pluripotent stem cells (hiPSC) for clinically healthy humans, which can be used as a valuable resource in vitro for normal control human development, genotype-phenotype association research, many disease models And drug response assessment

How it works: This hiPSC library of gender balance, racial and ethnic diversity was generated from 40 clinically healthy male and female individuals aged 22 to 61

In addition, the library also has similar transcriptome profiles, single-cell RNA-seq-derived cell clusters, and the physiological characteristics of cardiomyocytes differentiated from multiple independent hiPSC lines

Interesting reason for the study: The study is an important technological development that can be used for accurate cell models for drug discovery and prediction of adverse drug reactions

Dr.

Article title

A library of induced pluripotent stem cells from clinically well-characterized, diverse healthy human individuals