Mov Disord: DTI study found that free water in the dorsal medial nucleus of the thalamus is associated with cognitive decline in Parkinson's disease

Brain diffusion tensor imaging (DTI) can reflect cognitive changes in early Parkinson's disease (PD), but the measurement of free water (FW) based on the diffusion sequence has not been evaluated
.

FW assessment based on the dispersion sequence has been shown to be more sensitive to the longitudinal changes of substantia nigra in PD patients than conventional DTI

Thomas Guttus et al.
chose FW as the main result imaging evaluation method for these comparisons
.

They hypothesized that the 1-year longitudinal change in FW in one or more major ROIs was negatively correlated with the 1-year and 3-year longitudinal changes in the MoCA score

Thomas Guttus et al.

This study assessed whether the FW of the thalamus is mainly involved in cognitive functions (ie, the dorsal medial nucleus and pronucleus), whether Meynert basal nucleus (nbM) and the hippocampus are associated with longitudinal cognitive decline, and distinguished the baseline cognition of patients with early Parkinson's disease Status
.

In addition, discuss the comparison between FW and conventional DTI, FW-corrected DTI, and the volume evaluation of these results

Partial correlation analysis and ANCOVA method were used to analyze the imaging data and the Montreal Cognitive Assessment (MoCA) score in the Parkinson’s Disease Progression Marker Program database
.

The main results of the correlation between free water assessment and cognitive ability in Parkinson's disease

The main results of the correlation between free water assessment and cognitive ability in Parkinson's disease

The main findings are:

The main research results are: The main research results are:

1.
The 1-year change in thalamic DMN FW is correlated with the 1-year and 3-year changes in MoCA (partial correlation coefficient=0.
222, q = 0.
040, n = 130; partial correlation coefficient=0.
229, q = 0.
040, n = 123; baseline average PD duration = 6.
85 months)
.

1.
The 1-year change in thalamic DMN FW is correlated with the 1-year and 3-year changes in MoCA (partial correlation coefficient=0.
222, q = 0.
040, n = 130; partial correlation coefficient=0.
229, q = 0.
040, n = 123; baseline average PD duration = 6.
85 months)
.

2.
The 1-year change in nbM FW is only related to the 3-year change in MoCA (0.
222, q = 0.
040)
.

2.
The 1-year change in nbM FW is only related to the 3-year change in MoCA (0.
222, q = 0.
040)
.

3.
Baseline hippocampal FW is associated with 3-year cognitive impairment (q = 0.
040), and baseline nbM FW distinguishes PD-normal cognition (MoCA≥26) and PD-cognitive impairment (MoCA≤25) (q = 0.
008)
.

3.
Baseline hippocampal FW is associated with 3-year cognitive impairment (q = 0.
040), and baseline nbM FW distinguishes PD-normal cognition (MoCA≥26) and PD-cognitive impairment (MoCA≤25) (q = 0.
008)
.

Exploratory comparison shows that FW is the most reliable evaluation method
.

Exploratory comparison shows that FW is the most reliable evaluation method
.

Exploratory comparison shows that FW is the most reliable evaluation method

The FW of the dorsal medial nucleus of the thalamus is a promising biomarker for the early cognitive progression of Parkinson's disease, which helps to identify cognitive protective therapies in clinical trials

Guttuso T Jr, Sirica D, Tosun D, ​​et al.

Guttuso T Jr, Sirica D, Tosun D, ​​et al.
Thalamic Dorsomedial Nucleus Free Water Correlates with Cognitive Decline in Parkinson's Disease [published online ahead of print, 2021 Dec 22].
  Mov Disord .
2021;10.
1002/mds.
28886.
doi: 10.
1002/mds.
28886 Guttuso T Jr, Sirica D, Tosun D, ​​et al.
Thalamic Dorsomedial Nucleus Free Water Correlates with Cognitive Decline in Parkinson's Disease [published online ahead of print, 2021 Dec 22].
  Mov Disord .
2021;10.
1002/mds .
28886.
doi:10.
1002/mds.
28886 Mov Disord leave a message here