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    Home > Active Ingredient News > Study of Nervous System > Mov Disord: Parkinson: Which proteins in cerebrospinal fluid affect the homeostasis of synuclein

    Mov Disord: Parkinson: Which proteins in cerebrospinal fluid affect the homeostasis of synuclein

    • Last Update: 2021-08-14
    • Source: Internet
    • Author: User
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    In most patients with α-synuclein diseases, such as Parkinson's disease (PD) and Lewy body dementia (DLB), the common pathological feature is the accumulation of abnormal conformations of α-synuclein
    .

    Subsequently, several molecular pathways related to the homeostasis of α-synuclein protein were discovered in genetic research and cell and animal models
    .


    These pathways include impaired autophagy, such as endolysosomal dysfunction, ubiquitin-proteasome system, mitochondrial homeostasis, and synaptic plasticity


    However, there is a lack of effective biomarkers, which are clearly disease and/or pathway specific in human biological fluids



    (3) The CSF level of these proteins is positively correlated with the CSF level of total alpha-synuclein, that is, those proteins with low protein homeostasis have lower content and are related to the low level of total alpha-synuclein
    .

    (4) These findings can be confirmed longitudinally
    .


    Compared with PD patients with a normal protease profile, PD patients with a low CSF protease profile show lower levels of α-synuclein in the longitudinal direction


    The important significance of this research lies in the discovery: CSF protein related to neurotransmitter secretion, synaptic plasticity, and endolysosomal autophagy may be used as a organism related to the homeostasis of α-synucleotide protein in PD and DLB Markers
    .


    Original source:


    The CSF protein related to neurotransmitter secretion, synaptic plasticity and endolysosomal autophagy may be used as a biomarker related to the homeostasis of α-synucleotide protein in PD and DLB
    .
    The CSF protein related to neurotransmitter secretion, synaptic plasticity and endolysosomal autophagy may be used as a biomarker related to the homeostasis of α-synucleotide protein in PD and DLB
    .
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