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    Home > Active Ingredient News > Endocrine System > MSG is easier to gain weight than fructose?

    MSG is easier to gain weight than fructose?

    • Last Update: 2021-11-03
    • Source: Internet
    • Author: User
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    More than a hundred years ago, humans discovered MSG (MSG).
    It can be said that it is fresh and salty, and it has a unique advantage in the natural preference map of human taste buds
    .
    Then, as the people's demand for delicious food increased day by day, the development of monosodium glutamate production industry was unprecedented
    .
    However, people are afraid of being famous and afraid of being strong, and various researches on whether it is good or bad are increasing day by day, but the conclusions are mixed
    .

    More than a hundred years ago, humans discovered MSG (MSG).
    It can be said that it is fresh and salty, and it has a unique advantage in the natural preference map of human taste buds
    .
    Then, as the people's demand for delicious food increased day by day, the development of monosodium glutamate production industry was unprecedented
    .
    However, people are afraid of being famous and afraid of being strong, and various researches on whether it is good or bad are increasing day by day, but the conclusions are mixed
    .

     

     

    The predecessors have conducted research on whether MSG can increase obesity, but there is no unified conclusion
    .
    The University of Colorado team put forward a bold hypothesis, "Umami foods can promote obesity and metabolic syndrome independent of the fructose pathway.
    " The research results were published in "Nature Metabolism"
    .
    From the research results, MSG can turn mice into fat mice, and AMPD2 plays a key role in it.
    By reducing AMPD2, it can treat MSG-induced metabolic syndrome
    .

    The predecessors have conducted research on whether MSG can increase obesity, but there is no unified conclusion
    .
    The University of Colorado team put forward a bold hypothesis, "Umami foods can promote obesity and metabolic syndrome independent of the fructose pathway.
    " The research results were published in "Nature Metabolism"
    .
    Metabolic Syndrome From the research results, MSG can turn mice into fat mice.
    Among them, AMPD2 plays a key role.
    By reducing AMPD2, MSG-induced metabolic syndrome can be treated
    .

     

     

     

    The researchers observed in adult wild-type mice that compared with mice with low MSG doses in drinking water, mice with high doses had a significant increase in their daily intake of water and food, while using 60mM and 300mM MSG doses The weight of the mice increased by 3.
    2g (12.
    8%) and 4.
    8g (19.
    2%) respectively within 2 weeks
    .

    The researchers observed in adult wild-type mice that compared with mice with low MSG doses in drinking water, mice with high doses had a significant increase in their daily intake of water and food, while using 60mM and 300mM MSG doses The weight of the mice increased by 3.
    2g (12.
    8%) and 4.
    8g (19.
    2%) respectively within 2 weeks
    .

     

     

    The higher the MSG dose received by the mice, the higher the water intake and the higher the level of uric acid in the body

    The higher the MSG dose received by the mice, the higher the water intake and the higher the level of uric acid in the body

     

     

    In another set of studies, researchers found that the level of uric acid in the liver of mice fed with MSG significantly increased, while ATP and AMPD (the first enzyme in the purine degradation pathway) were significantly reduced.
    Regular consumption of MSG has made mice perfect Have the basis for suffering from metabolic syndrome
    .

    In another set of studies, researchers found that the level of uric acid in the liver of mice fed with MSG significantly increased, while ATP and AMPD (the first enzyme in the purine degradation pathway) were significantly reduced.
    Regular consumption of MSG has made mice perfect Have the basis for suffering from metabolic syndrome
    .

     

     

    In order to prove that MSG and fructose are the culprits of metabolic syndrome, the mice were fed the same dose (300mM) of MSG and fructose respectively, and the subsequent development of the two groups of mice was observed
    .
    The body weight, liver and epididymis weight, liver fat content, and aspartate aminotransferase of the mice that ate MSG skyrocketed.
    The results were consistent with the fructose group, and even higher than the fructose group.
    The mice had successfully become patients with metabolic syndrome
    .

    In order to prove that MSG and fructose are the culprits of metabolic syndrome, the mice were fed the same dose (300mM) of MSG and fructose respectively, and the subsequent development of the two groups of mice was observed
    .
    The body weight, liver and epididymis weight, liver fat content, and aspartate aminotransferase of the mice that ate MSG skyrocketed.
    The results were consistent with the fructose group, and even higher than the fructose group.
    The mice had successfully become patients with metabolic syndrome
    .

     

     

    So, how does MSG work in the body?

    So, how does MSG work in the body?

     

     

    MSG, that is, sodium glutamate, is absorbed from the intestine, it is metabolized into glutamine in the liver, and then enters the purine metabolism pathway, where it first generates inosine acid (IMP) under the action of adenosine monophosphate deaminase (AMPD2).
    ), which is finally metabolized into uric acid.
    The accumulation of uric acid will increase the appetite of mice, leading to a significant increase in caloric intake
    .

    MSG, that is, sodium glutamate, is absorbed from the intestine, it is metabolized into glutamine in the liver, and then enters the purine metabolism pathway, where it first generates inosine acid (IMP) under the action of adenosine monophosphate deaminase (AMPD2).
    ), which is finally metabolized into uric acid.
    The accumulation of uric acid will increase the appetite of mice, leading to a significant increase in caloric intake
    .

     

     

    Studies have confirmed that compared with wild mice, liver and brain-specific AMPD2 knockout mice have similar food intake, but their preference for monosodium glutamate is significantly lower than that of wild mice.
    At the same time, the level of uric acid in the liver of AMPD2 knockout mice is also higher than that of wild mice.
    Lower
    .
    This also shows from the side that reducing AMPD2 can successfully help mice stay away from the temptation of MSG
    .

    Studies have confirmed that compared with wild mice, liver and brain-specific AMPD2 knockout mice have similar food intake, but their preference for monosodium glutamate is significantly lower than that of wild mice.
    At the same time, the level of uric acid in the liver of AMPD2 knockout mice is also higher than that of wild mice.
    Lower
    .
    This also shows from the side that reducing AMPD2 can successfully help mice stay away from the temptation of MSG
    .

     

     

    AMPD2 knockout mice have significant differences in MSG preference, water intake, uric acid levels, ATP and wild mice

    AMPD2 knockout mice have significant differences in MSG preference, water intake, uric acid levels, ATP and wild mice

     

     

    In addition, because IMP is not only a metabolite of sodium glutamate, it can also enhance the sensitivity of taste buds to MSG and make MSG jump wildly on human taste buds.
    Therefore, by increasing IMP alone, the effect of MSG's weight gain is almost twice the result with half the effort
    .

    In addition, because IMP is not only a metabolite of sodium glutamate, it can also enhance the sensitivity of taste buds to MSG and make MSG jump wildly on human taste buds.
    Therefore, by increasing IMP alone, the effect of MSG's weight gain is almost twice the result with half the effort
    .

     

     

    MSG-induced metabolic syndrome mechanism

    MSG-induced metabolic syndrome mechanism

     

     

    Combining brain signals and research results, it was found that while calorie intake increased, the levels of leptin in plasma and adipose tissue of mice receiving MSG+IMP increased significantly.
    What is more tragic is that leptin appeared in the first two weeks.
    Resistance, and the hypothalamic uric acid level is significantly increased, and there is a clear correlation between the two, that is to say, just the early crazy intake of MSG and IMP, the effect of increasing weight is already very significant
    .

    Combining brain signals and research results, it was found that while calorie intake increased, the levels of leptin in plasma and adipose tissue of mice receiving MSG+IMP increased significantly.
    What is more tragic is that leptin appeared in the first two weeks.
    Resistance, and the hypothalamic uric acid level is significantly increased, and there is a clear correlation between the two, that is to say, just the early crazy intake of MSG and IMP, the effect of increasing weight is already very significant
    .

     

     

    Although this study has found so many MSG unhealthy aspects, the current per capita intake of MSG in the UK is 500-550mg/d, and in Japan it can reach 1.
    2-1.
    7g/d, while in China, which is "on the tip of the tongue", MSG The per capita intake can reach 1.
    9g/d
    .
    Mr.
    Chua Lan said, “Good food is unhealthy”.
    Now that the research has found target genes that can interfere with the mechanism of sodium glutamate, I believe it will not be the day when “you can eat good food without losing weight”.
    Far away
    .

    Although this study has found so many MSG unhealthy aspects, the current per capita intake of MSG in the UK is 500-550mg/d, and in Japan it can reach 1.
    2-1.
    7g/d, while in China, which is "on the tip of the tongue", MSG The per capita intake can reach 1.
    9g/d
    .
    Mr.
    Chua Lan said, “Good food is unhealthy”.
    Now that the research has found target genes that can interfere with the mechanism of sodium glutamate, I believe it will not be the day when “you can eat good food without losing weight”.
    Far away
    .

     

     

    references:

    references:

    Andres-Hernando A, Cicerchi C, Kuwabara M, et al.
    Umami-induced obesity and metabolic syndrome is mediated by nucleotide degradation and uric acid generation[J].
    Nature Metabolism, 2021, 3(9): 1189-1201.

    Andres-Hernando A, Cicerchi C, Kuwabara M, et al.
    Umami-induced obesity and metabolic syndrome is mediated by nucleotide degradation and uric acid generation[J].
    Nature Metabolism, 2021, 3(9): 1189-1201.


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