MSG is easier to gain weight than fructose?

More than a hundred years ago, humans discovered MSG (MSG).

More than a hundred years ago, humans discovered MSG (MSG).

 

The predecessors have conducted research on whether MSG can increase obesity, but there is no unified conclusion

The predecessors have conducted research on whether MSG can increase obesity, but there is no unified conclusion

 

 

The researchers observed in adult wild-type mice that compared with mice with low MSG doses in drinking water, mice with high doses had a significant increase in their daily intake of water and food, while using 60mM and 300mM MSG doses The weight of the mice increased by 3.

The researchers observed in adult wild-type mice that compared with mice with low MSG doses in drinking water, mice with high doses had a significant increase in their daily intake of water and food, while using 60mM and 300mM MSG doses The weight of the mice increased by 3.

 

The higher the MSG dose received by the mice, the higher the water intake and the higher the level of uric acid in the body

The higher the MSG dose received by the mice, the higher the water intake and the higher the level of uric acid in the body

 

 

In another set of studies, researchers found that the level of uric acid in the liver of mice fed with MSG significantly increased, while ATP and AMPD (the first enzyme in the purine degradation pathway) were significantly reduced.

In another set of studies, researchers found that the level of uric acid in the liver of mice fed with MSG significantly increased, while ATP and AMPD (the first enzyme in the purine degradation pathway) were significantly reduced.

 

In order to prove that MSG and fructose are the culprits of metabolic syndrome, the mice were fed the same dose (300mM) of MSG and fructose respectively, and the subsequent development of the two groups of mice was observed

In order to prove that MSG and fructose are the culprits of metabolic syndrome, the mice were fed the same dose (300mM) of MSG and fructose respectively, and the subsequent development of the two groups of mice was observed

 

So, how does MSG work in the body?

So, how does MSG work in the body?

 

 

MSG, that is, sodium glutamate, is absorbed from the intestine, it is metabolized into glutamine in the liver, and then enters the purine metabolism pathway, where it first generates inosine acid (IMP) under the action of adenosine monophosphate deaminase (AMPD2).

MSG, that is, sodium glutamate, is absorbed from the intestine, it is metabolized into glutamine in the liver, and then enters the purine metabolism pathway, where it first generates inosine acid (IMP) under the action of adenosine monophosphate deaminase (AMPD2).

 

Studies have confirmed that compared with wild mice, liver and brain-specific AMPD2 knockout mice have similar food intake, but their preference for monosodium glutamate is significantly lower than that of wild mice.

Studies have confirmed that compared with wild mice, liver and brain-specific AMPD2 knockout mice have similar food intake, but their preference for monosodium glutamate is significantly lower than that of wild mice.

 

AMPD2 knockout mice have significant differences in MSG preference, water intake, uric acid levels, ATP and wild mice

AMPD2 knockout mice have significant differences in MSG preference, water intake, uric acid levels, ATP and wild mice

 

 

In addition, because IMP is not only a metabolite of sodium glutamate, it can also enhance the sensitivity of taste buds to MSG and make MSG jump wildly on human taste buds.

In addition, because IMP is not only a metabolite of sodium glutamate, it can also enhance the sensitivity of taste buds to MSG and make MSG jump wildly on human taste buds.

 

MSG-induced metabolic syndrome mechanism

MSG-induced metabolic syndrome mechanism

 

 

Combining brain signals and research results, it was found that while calorie intake increased, the levels of leptin in plasma and adipose tissue of mice receiving MSG+IMP increased significantly.
What is more tragic is that leptin appeared in the first two weeks.
Resistance, and the hypothalamic uric acid level is significantly increased, and there is a clear correlation between the two, that is to say, just the early crazy intake of MSG and IMP, the effect of increasing weight is already very significant
.

Combining brain signals and research results, it was found that while calorie intake increased, the levels of leptin in plasma and adipose tissue of mice receiving MSG+IMP increased significantly.
What is more tragic is that leptin appeared in the first two weeks.
Resistance, and the hypothalamic uric acid level is significantly increased, and there is a clear correlation between the two, that is to say, just the early crazy intake of MSG and IMP, the effect of increasing weight is already very significant
.

 

 

Although this study has found so many MSG unhealthy aspects, the current per capita intake of MSG in the UK is 500-550mg/d, and in Japan it can reach 1.
2-1.
7g/d, while in China, which is "on the tip of the tongue", MSG The per capita intake can reach 1.
9g/d
.
Mr.
Chua Lan said, “Good food is unhealthy”.
Now that the research has found target genes that can interfere with the mechanism of sodium glutamate, I believe it will not be the day when “you can eat good food without losing weight”.
Far away
.

Although this study has found so many MSG unhealthy aspects, the current per capita intake of MSG in the UK is 500-550mg/d, and in Japan it can reach 1.
2-1.
7g/d, while in China, which is "on the tip of the tongue", MSG The per capita intake can reach 1.
9g/d
.
Mr.
Chua Lan said, “Good food is unhealthy”.
Now that the research has found target genes that can interfere with the mechanism of sodium glutamate, I believe it will not be the day when “you can eat good food without losing weight”.
Far away
.

 

 

references:

references:

Andres-Hernando A, Cicerchi C, Kuwabara M, et al.
Umami-induced obesity and metabolic syndrome is mediated by nucleotide degradation and uric acid generation[J].
Nature Metabolism, 2021, 3(9): 1189-1201.

Andres-Hernando A, Cicerchi C, Kuwabara M, et al.
Umami-induced obesity and metabolic syndrome is mediated by nucleotide degradation and uric acid generation[J].
Nature Metabolism, 2021, 3(9): 1189-1201.


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