Multiple articles focus on the close relationship between gut microbiotics and the occurrence of multiple human diseases!

in recent years, there has been more and more research evidence that the body's gut microbiome is directly related to the occurrence of a variety of human diseases. FILE PHOTO: scitecheuropa.eu Cell Rep: The relationship between gut microbes and cancer severity Doi:10.1016/j.celrep.2020.03.035 In a recent study, researchers at the Rogers Cancer Center at the University of Michigan provided new clues as to how microbes in the gastrointestinal tract affect the development of colorectal cancer.
The researchers found that certain types of gut bacteria are more effective in stimulating certain immune cells in the body, especially CD8-T cells, which often help protect the body from cancer, but overstating them can promote inflammation and deplete T-cells -- in fact, according to the study published in the journal Cell Reports, over-activation of immune cells may increase susceptivity to cancer.
researchers say the work, which will help scientists determine which bacterial populations have properties that inhibit tumors or promote tumor occurrence, suggests that the effects of the gut microbiome on cancer may be a double-edged sword -- promoting T-cell failure is something researchers need to pay special attention to.
current study builds on previous work by Chen's team, which found that interference from the gut microbiome can directly lead to cancer.
mice from two different study colonies had very different susceptible to colorectal cancer after exposure to a carcinogen and substance that promotes inflammation of the gastrointestinal tract.
in-depth analysis of the 2nd! How does the gut microbiome interconnect with the immune system to induce bile siltation liver disease? doi:10.1002/hep.31228 Today, a growing body of research suggests a link between bile siltation liver disease and changes in the composition of the body's microbiome, but researchers are not aware of the key role of the microbiome in the pathogenesis of the disease; In a study published in the journal Hepatology entitled "Intestinal microbiome-macrophage crosstalk contributes to cholestatic liver by promoting intestinal permeability", scientists from institutions such as the Quadram Institute of Biological Sciences have developed an in-depth analysis of how gut microbes interact with immune system cells to induce the occurrence of bile siltation liver disease.
The body's intestines are a selective barrier that blocks the entry of pathogenic bacteria into the body, while at the same time facilitating the body's absorption of nutrients, and in the intestines, crosstalk connections between the microbiome, immune cells, and endocrine cells are essential to maintain the body's intestinal barrier function;
In the gut, the microbiome shapes the immune system to provide a toned environment in which microorganisms and host cells coexist, and instead, inflammation determines the composition of the gut microbiome, adding another layer of complexity to the regulation of intestinal permeability and barrier function.
3 Nature Sub-Journal: Gut microbes cause colorectal cancer through broken intestinal walls! Doi:10.1038/s43018-020-0070-2 A cooperative study by a team from the VIB-UGent Center for Inflammation Research and the University of Dent at the Flanders Biotechnology Institute in Belgium reveals a new mechanism for colorectal cancer.
found that abnormal expressions of Zeb2 protein affect the integrity of the intestinal wall or 'skin'.
normally, this corted cell acts as a barrier against the penetration of gut microbes.
" Zeb2 breaks this barrier and allows permeable bacteria to cause inflammation, which can lead to cancer progress.
, scientists have shown that controlling the immune system or removing the microbiome can prevent cancer from developing.
findings could lead to new treatments, the findings, published in the international journal Nature Cancer.
colorectal cancer is the third most common cancer and the fourth deadliest.
, anti-cancer therapies, including immunotherapy, are relatively ineffective in colorectal cancer.
addition to genetic factors, environmental factors associated with Western lifestyles, such as diet, obesity and sedentary lifestyles, also increase the risk of colorectal cancer, a disease that originates in the intestinal cortectal cells.
over time, these "barrier" cells accumulate mutations and develop malignant properties, and a better understanding of the molecular mechanisms responsible for the development of colorectal cancer is critical to developing new treatments to effectively combat this deadly disease.
: The Gut Microbiome may be able to convert stress to sickle cell disease doi:10.1016/j.immuni.2020.06.025 In a study published in the international journal Immunity, scientists from institutions such as the Albert Einstein College of Medicine Studies in mice have revealed how chronic psychological stress can lead to painful vascular blockage attacks, a common complication of sickle-cell disease (SCD, sickle-cell disease) and the leading cause of hospitalization;
SCDs make up about 1/365 of the African-American population, and patients usually carry a genetic mutation that causes abnormal hemoglobin production, which promotes red blood cells to become sickle-like and less flexible, and how sickle-like red blood cells block small blood vessels, block blood flow, and oxygen reaches tissue. This may lead to painful and weakened vasodilation seizures (VOEs) that last for several days; there is currently no therapy to reverse VOE, and over time it can cause serious damage to the internal organs, which is the main reason why life expectancy in severe SCD patients is 20-30 years lower than in non-SCD patients.
/Physiol Geno: Uncovering the mysterious link between poor sleep quality, high blood pressure, and the body's gut microbiome! doi:10.1152/physiolgenomics.00039.2020 In a recent study published in the international journal Physiology Genomics, scientists from the University of Illinois and others The study revealed a link between sleep disturbance, high blood pressure, and changes in the gut microbiome, which the researchers wanted to identify biological characteristics associated with poor arterial blood pressure changes, by determining whether 28 days of sleep disturbance altered the microbiome in rats.
Using rats for research, the researchers interfered with the sleep cycles of rats, which were nocturns, so the experiments they designed interfered with their sleep cycles during the day, using telemetry transmitters to measure brain activity, blood pressure and heart rate in rats, as well as analyzing their feces Researcher Maki said that when a rat's sleep cycle or schedule is abnormal, its blood pressure increases, and even when its sleep cycle returns to normal, its body's blood pressure remains elevated, suggesting that dysfunctional sleep may impair the body's health for some time.
Photo Source: Wikimedia 6 News Reading Directly Related to Hypertension and Depression: New Research Suggests Gut bacteria May Be Linked to High Blood Pressure and depression Recently, scientists from the University of Florida reported their latest findings at the American Heart Association's 2019 Scientific Meeting on Hypertension.
researcher Bruce R. Stevens said the human population consists of a complex of roughly the same number of cells and bacteria, and that there is a certain interaction between the ecology of the gut microbiome and the body's physiology and brain, which can lead to high blood pressure and depression in some people.
health experts may be able to target the body's intestines to suppress, diagnose and selectively treat different forms of hypertension.
researchers are now expected to develop new therapies based on current research to improve treatment for patients with high blood pressure that is resistant to the treatment, with about 20 percent of patients with high blood pressure not responding to the treatment or even to multiple drugs.
The researchers extracted DNA from the gut bacteria of 105 volunteer body feces samples and then used new techniques, including artificial intelligence software, to analyze the bacteria, revealing four different types of bacterial genes and characteristic molecules;
: Obesity is associated with intestinal bacteria disorders, and statins can enhance intestinal bacterial diversity! Doi:10.1038/s41586-020-2269-x2012 The European Union MetaCardis Consortium, a group of 14 research groups with multidisciplinary expertise from six European countries, began investigating the potential role of the gut microbiome in the development of heart metabolic diseases.
project, coordinated by Professor Karine Clement of INSERM in France, looked at the esopes of heart metabolic diseases (obesity, diabetes and cardiovascular disease) in the health phase of more than 2,000 Europeans.
recently, a team led by Jeroen Raes (VIB-KU Leuven) and Professor Clement (INSERM), together with the Metacardis Society, published their first findings in the authoritative journal Nature, identifying the common cholesterol-lowering drug statins as a potential microbial regulatory treatment.
paper, entitled "Statin therapy associates with lower levels of contention of gut microbiota dysbiosis", Jeroen Raes (VIB-KU Leuven) and his colleagues studied gut bacteria in the Metacardis queue, which consists of nearly 900 people from three countries (France, Denmark and Germany) with a body mass index of between 18 and 73 kg/m2.
Although the gut microbiomes of obese individuals have previously been shown to be different from those of thin people, the unique experience of TheRaes laboratory in quantitative microbiome analysis has allowed researchers to gain a new understanding of the changes in the obesity-related microbiome.
Hypertension: Why does the body's arteries function worse as we get older? New research has found that this may be closely related to gut bacteria and daily diet! Doi:10.1161/HYPERTENSIONAHA.120.14759 In a study published in the international journal Hypertension, scientists from the University of Colorado and others found that when we eat red meat, the intestines may produce a special compound that damages the body's arteries and plays an important role in promoting the body's risk of heart disease as the body ages.
study suggests that people may prevent or even reverse age-related diseases through dietary changes and targeted therapies, such as new nutritional supplements.
researcher Vienna Brunt said the study is the first to show that the compound produced by the gut microbiome not only directly impairs arterial function, but also helps explain why damage occurs to the body's cardiovascular system as it ages.
Eat a large steak or a plate of scrambled eggs, the gut bacterium in the body immediately breaks it down, and when the gut bacterium metabolizes the amino acids L-carnitine and choline, it produces a metabolic by-product called trimethylamine, which the liver converts into TMAO and circulates in the blood.
-Cell Host Microbe: Uncovering the close link between gut microbiota and human fatty liver disease! doi:10.1016/j.chom.2020.07.007 A recent article in the international magazine Cell Host and Microbe entitled "Microbiota and Fatty Liver Disease-the, The Unknown, and The Future"