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Multiple sclerosis Journal: Looking for suspected culprits of cortical axon loss in PMS patients

 Last Update: 2021-03-21
 Source: Internet
 Author: User

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Multiple sclerosis (MS) is a central nervous system disease characterized by inflammation, demyelination, and neurodegeneration of white matter (WM) and gray matter (GM).

Svenja Kiljan et al.

They collected the autopsy 3T magnetic resonance imaging (MRI) and cerebral cortex tissues of 16 PMS body donors and 10 controls.

Compared with the control group, the demyelinated cortex and the normal appearance (NA) cortex of the PMS group had significant axon loss.

Table note: Differences in cortical axon measurement, myelin density and microglia density between groups

Legend: Correlation of white matter pathological changes and cortical pathological changes with cortical axon loss

In summary, the decreased integrity of the WM bundles and cortical demyelination in PMS patients are related to the loss of cortical axons.

In summary, the reduced integrity of WM WM bundles and cortical demyelination of patients connected to PMS PMS patients are related to the loss of cortical axons.

Original source: Kiljan Svenja, Preziosa Paolo, Jonkman Laura E et al.

sagepub.
com/doi/full/10.
1177/1352458520918978" target="_blank" rel="noopener">Cortical axonal loss is associated with both gray matter demyelination and white matter tract pathology in progressive multiple sclerosis: Evidence from a combined MRI-histopathology study in this message

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