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    Home > Biochemistry News > Biotechnology News > Mutation Screening Using PCR-SSCP: Silver Staining and Isotopic Protocols

    Mutation Screening Using PCR-SSCP: Silver Staining and Isotopic Protocols

    • Last Update: 2020-11-25
    • Source: Internet
    • Author: User
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    Screening for mutations prior to sequencing can reduce the time and costs of identifying mutations. When the
    DNA
    sequence is known, the technique of detecting mutations as single-stranded conformational polymorphisms (SSCP) is a convenient method of screening for possible mutations. SSCP was originally developed by Orita et al. (
    1
    ). It has the ability of detecting a single base change, and has been applied to a number of genes, including the insulin receptor (
    2
    ), GLUT 4 (
    3
    ), glucokinase (
    4
    ), and the mitochondrial genome (
    5
    ).
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