My scientist discovered for the first time the developmental path of natural lymphocytes outside the bone marrow

Academician Tian Zhigang, Professor Peng Hui, and Professor Sun X of the University of Science and Technology of China collaborated with the team of Professor Eric Vivier from the University of Marseille in France to discover the differentiation of adult hematopoietic precursor cells into type 1 natural lymphocytes (liver-resident NK cells) for the first time Potential and regulatory mechanism, which reveals the new path of natural lymphocytes outside the bone marrow development, provides an important theoretical basis for explaining the formation of the liver's natural immune dominant state.

It is generally believed that the bone marrow is the main hematopoietic organ after birth, and the renewal and replenishment of immune cells depends on bone marrow hematopoiesis.

The research group compared fetal liver, adult liver, bone marrow and peripheral blood hematopoietic precursor cells and found that there are a group of LSM cells similar to fetal liver hematopoietic stem cells in adult mouse liver.