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    Home > Medical News > Latest Medical News > My scientists designed new nano-weapons to strike cancer cells with precision

    My scientists designed new nano-weapons to strike cancer cells with precision

    • Last Update: 2020-12-11
    • Source: Internet
    • Author: User
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    traditional cancer chemotherapy has a series of problems in targeting, drug resistance, side effects, metastasis recurrence and so on. Recently, Zhao Yanjun and Wang Zheng of Tianjin University's School of Pharmaceutical Science and Technology designed a new nano-drug carrier based on the cell iron death process, which has the characteristics of selectivity and broad spectrum, and is expected to effectively eliminate solid tumor cells under the premise of "zero damage" to normal cells.
    iron death is a new type of cell death method dependent on iron ions, which is different from other cell death pathways such as apoptosis and autophagy in morphology, biogenetic and genetic characteristics. The prototype niacin adenine dinucleotide phosphate (NADPH) is one of the key molecules to maintain the steady state of redox in cells, and the researchers found that by selectively consuming NADPH in tumor cells, the iron death of tumor cells was enhanced.
    Zhao Yanjun, Professor Wang Zheng team designed a polymer nano-beam carrier, including "azobenzene" and "nitromide" two functional groups, with dual hypoxia sensitivity, can achieve the effect of iron death of sensitive cells. At the same time in the nano-glue beam containing small molecule iron death agent, selectively attack cancer cells.
    team modeled breast cancer cells in mice, and the results showed that this polymer vector not only enhances the drug intake of tumor cells, achieves controlled release of drugs within the cells, but also consumes NADPH in tumor cells, thus increasing the iron death of tumor cells. The team said that because of the significant difference in oxygen concentration between anaerobic solid tumors and normal oxygen tissues, the iron death sensitivity of such vectors was limited to tumor cells and was virtually toxic to normal cells.
    this result has three major advantages: First, selectivity, according to whether lack of oxygen to distinguish tumor tissue and normal organs / tissue, can reduce the healthy cells "mistaken injury." Second, broad-spectrum, for all types of oxygen-deprived solid tumors have efficacy. Third, resistance to drugs, drug-resistant cells based on apoptosis is highly sensitive.
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