N-3 polyunsaturated fatty acids reduce fat accumulation in liver

Recently, researchers from Zhejiang University and Qingdao University found new evidence that n-3 polyunsaturated fatty acids can significantly reduce the concentration of alanine aminotransferase (ALT), aspartate aminotransferase (AST) and triglyceride (tag), and slightly reduce the accumulation of fat in the liver The results of the study have been published in the Journal of clinical nutrition The researchers said the results of this study will provide a lot of help for nonalcoholic fatty liver disease (NAFLD) However, in previous studies, researchers found that the liver fatty acid content of healthy people (http://www.chemdrug.com/article/7/) was inconsistent with that of NAFLD patients However, the results of alt, AST and tag are consistent Therefore, in this study, the researchers focused on the difference of liver fatty acid concentration between healthy people and NAFLD people, and the effect of n-3 polyunsaturated fatty acids on NAFLD patients During the trial (http://www.chemdrug.com/sell/24/), the researchers measured the concentration of fatty acids in the liver of two different populations, marked by the weighted mean difference (WMD), and assessed the levels of alt, AST, liver fat, tag and fasting blood glucose in volunteers with WMD The results show that n-3 polyunsaturated fatty acids, especially DHA, may play an active role in the treatment of NAFLD, and 11 RCTs tests provide sufficient basis for the results of this study The researchers believe that there are three possible mechanisms for the action of n-3 polyunsaturated fatty acids on NAFLD, perhaps because this component can promote the synthesis of tag (http://www.chemdrug.com/article/8/), accelerate the oxidation of lipids in the liver, increase the fluidity of cell membrane, and finally reduce the risk of NAFLD, while the anti-inflammatory effect of this component can prevent the deterioration of the disease It is understood that researchers will conduct larger trials to determine the most effective dose of n-3 PUFA In addition, because EPA, DPA and DHA have both independent and synergistic effects on human health, researchers need to conduct animal experiments with high-purity EPA, DHA and DPA in order to evaluate the mechanism of DHA on NAFLD at the molecular level