N Engl J Med: How effective is the third shot of BNT162b2 vaccine in neutralizing Omicron?

On November 26, 2021, the World Health Organization (WHO) named the Severe Acute Respiratory Syndrome Coronavirus Type 2 (SARS-CoV-2) variant strain first discovered in South Africa as B.
1.
1.
529 (omicron)
.

At present, cases of omicron variants have been found in many other countries

It has been shown to before BNT162b2 vaccine (Pfizer-BioNTech) COVID-19 with a 95% effectiveness, but will effectively neutralize omicron variant of the infection is unknown
.

We compared the neutralization effect of omicron-infected cells in serum samples of participants who received two doses of the vaccine with those of participants who received three doses of vaccine

COVID-19 infection

experimental method:

Experimental method: Experimental method:

Using serum samples obtained from two groups of 20 medical staff, the wild-type virus and B.
1.
351 (beta), B.
1.
617.
2 (delta) and omicron mutant isolates were used for micro-neutralization experiments
.

One group included participants who received 2 doses of the BNT162b2 vaccine (average, 165.

Experimental results:

Experimental results: Experimental results:

Receiving 3 doses of vaccine can neutralize the wild-type virus and 3 variants better than receiving 2 doses (Figure 1)
.

1).

Figure 1: Neutralization efficiency against wild-type viruses and variants of Beta, Delta and Omicron viruses

Figure 1: Neutralization efficiency against wild-type viruses and variants of Beta, Delta and Omicron viruses

in conclusion:

Conclusion: Conclusion:

We analyzed the neutralization efficiency of BNT162b2 vaccine against wild-type SARS-CoV-2 and β, δ and omicron variants
.

Limitations of the study include the small cohort of the test and the fact that the test is only an in vitro test

Two doses of BNT162b2 vaccine have low neutralization efficiency for wild-type virus and delta variants, but no neutralization efficiency for omicron variants

 

Original link: https://pubmed.

https://pubmed.

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