-
Categories
-
Pharmaceutical Intermediates
-
Active Pharmaceutical Ingredients
-
Food Additives
- Industrial Coatings
- Agrochemicals
- Dyes and Pigments
- Surfactant
- Flavors and Fragrances
- Chemical Reagents
- Catalyst and Auxiliary
- Natural Products
- Inorganic Chemistry
-
Organic Chemistry
-
Biochemical Engineering
- Analytical Chemistry
- Cosmetic Ingredient
-
Pharmaceutical Intermediates
Promotion
ECHEMI Mall
Wholesale
Weekly Price
Exhibition
News
-
Trade Service
Skin damage repair, especially large-area skin damage repair, is a worldwide probl.
On August 20th, news came from Nanjing University of Technology that Professor Chen Su from the State Key Laboratory of Materials Chemical Engineering and Professor Wang Gefei from Jinling Clinical School of Nanjing Medical University jointly explored a new strategy using microfluidic air-jet spinni.
The silk method prepares large-area and high-strength artificial skin, which shows great potential in the repair of abdominal wall defec.
So far, most research results have focused on the repair of small-area wound sk.
There are few studies on the protection of large-area burns and the exposure of abdominal viscera after the abdominal cavity is open.
This is mainly because after the abdominal cavity is opened, the wound area is larger than other parts, and it is prone to infection which hinders the healing of the wound, making the preparation and application of artificial skin materials the biggest challenge in the repair proce.
In response to this problem, Chen Su's research group explored a new strategy for preparing artificial sk.
The formation of artificial skin has mainly gone through three stages: preparation of nanofiber scaffolds loaded with a large area of biodegradable fibrin sealant, skin tissue formation and skin regenerati.
"Firstly, a large-scale nanofiber scaffold material was prepared by the microfluidic airjet spinning method, which was composed of nanofibers with an ultra-fine core-shell structu.
This core-shell structure uses polycaprolactone/silk fibroin as the core and fibrin Originally wrapped on the surface as a shell, the average fiber diameter is only 65 nanomete.
" Cui Tingting, the first author of the thesis and a doctoral student at Nanjing University of Technology, introduced that the nanofiber scaffold was used as a substrate and thrombin was sprayed on the substrate to allow the thrombin to interact with the surface of the scaffo.
The fibrinogen reacts and forms a fibrin gel adhesive on the surface of the nanofiber scaffold, which can be directly adhered to the wound without sutur.
"The composite fibrin glue-nanofiber scaffold formed at this stage is called artificial sk.
This artificial skin has excellent air permeability, mechanical strength and rapid degradation rate in the bo.
The material will also automatically degra.
" Cui Tingting sa.
The second stage is the skin tissue repair proce.
"In the experiment, we found new tissues, granulation, new blood vessels, and the wound was slowly shrinking, which indicates that the process of skin tissue repair has been complet.
This is mainly due to the antibacterial and anti-infective effect of the fibrin gel adhesi.
, And can promote the formation of new blood vessels and transport nutrients to the skin tiss.
" said Yu Jiafei, co-first author of the paper and a graduate student of Nanjing Medical Universi.
The third stage is the process of skin regenerati.
"In the experimental results, we finally found the regeneration of hair follicles, which indicates the final formation of new sk.
" Yu Jiafei introduced that hair follicles are important accessory organs of the sk.
When damaged, the body is often repaired by connective tissue without hair follicle structure, so that it loses the structure and function of the original tissue and forms incomplete pathological regenerati.
The regeneration of hair follicles can prove that the regeneration tissue with the same structure and function is formed, and the perfect regeneration of the epidermis is realiz.
"In vivo studies have shown that artificial skin materials have been applied to large-area skin defects in the rat abdomen in in vivo experiments, which can quickly repair large-area abdominal wall defects and promote wound tissue regenerati.
In addition, it avoids immune rejection and secondary effects in clinical applicatio.
The risk of secondary surge.
” Chen Su said that the research provides a simple way to regenerate large-scale tough skin, and shows broad application prospects in the field of abdominal wall defect repa.
(Zhou Wei)
On August 20th, news came from Nanjing University of Technology that Professor Chen Su from the State Key Laboratory of Materials Chemical Engineering and Professor Wang Gefei from Jinling Clinical School of Nanjing Medical University jointly explored a new strategy using microfluidic air-jet spinni.
The silk method prepares large-area and high-strength artificial skin, which shows great potential in the repair of abdominal wall defec.
So far, most research results have focused on the repair of small-area wound sk.
There are few studies on the protection of large-area burns and the exposure of abdominal viscera after the abdominal cavity is open.
This is mainly because after the abdominal cavity is opened, the wound area is larger than other parts, and it is prone to infection which hinders the healing of the wound, making the preparation and application of artificial skin materials the biggest challenge in the repair proce.
In response to this problem, Chen Su's research group explored a new strategy for preparing artificial sk.
The formation of artificial skin has mainly gone through three stages: preparation of nanofiber scaffolds loaded with a large area of biodegradable fibrin sealant, skin tissue formation and skin regenerati.
"Firstly, a large-scale nanofiber scaffold material was prepared by the microfluidic airjet spinning method, which was composed of nanofibers with an ultra-fine core-shell structu.
This core-shell structure uses polycaprolactone/silk fibroin as the core and fibrin Originally wrapped on the surface as a shell, the average fiber diameter is only 65 nanomete.
" Cui Tingting, the first author of the thesis and a doctoral student at Nanjing University of Technology, introduced that the nanofiber scaffold was used as a substrate and thrombin was sprayed on the substrate to allow the thrombin to interact with the surface of the scaffo.
The fibrinogen reacts and forms a fibrin gel adhesive on the surface of the nanofiber scaffold, which can be directly adhered to the wound without sutur.
"The composite fibrin glue-nanofiber scaffold formed at this stage is called artificial sk.
This artificial skin has excellent air permeability, mechanical strength and rapid degradation rate in the bo.
The material will also automatically degra.
" Cui Tingting sa.
The second stage is the skin tissue repair proce.
"In the experiment, we found new tissues, granulation, new blood vessels, and the wound was slowly shrinking, which indicates that the process of skin tissue repair has been complet.
This is mainly due to the antibacterial and anti-infective effect of the fibrin gel adhesi.
, And can promote the formation of new blood vessels and transport nutrients to the skin tiss.
" said Yu Jiafei, co-first author of the paper and a graduate student of Nanjing Medical Universi.
The third stage is the process of skin regenerati.
"In the experimental results, we finally found the regeneration of hair follicles, which indicates the final formation of new sk.
" Yu Jiafei introduced that hair follicles are important accessory organs of the sk.
When damaged, the body is often repaired by connective tissue without hair follicle structure, so that it loses the structure and function of the original tissue and forms incomplete pathological regenerati.
The regeneration of hair follicles can prove that the regeneration tissue with the same structure and function is formed, and the perfect regeneration of the epidermis is realiz.
"In vivo studies have shown that artificial skin materials have been applied to large-area skin defects in the rat abdomen in in vivo experiments, which can quickly repair large-area abdominal wall defects and promote wound tissue regenerati.
In addition, it avoids immune rejection and secondary effects in clinical applicatio.
The risk of secondary surge.
” Chen Su said that the research provides a simple way to regenerate large-scale tough skin, and shows broad application prospects in the field of abdominal wall defect repa.
(Zhou Wei)
