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    Home > Biochemistry News > Biotechnology News > Nano flu vaccine protects against seasonal flu

    Nano flu vaccine protects against seasonal flu

    • Last Update: 2022-05-13
    • Source: Internet
    • Author: User
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    According to a recent study, researchers have developed an experimental flu vaccine that protects animals from a variety of seasonal and pandemic strains of the flu
    .

    The vaccine is currently entering clinical trials
    .

    If proven safe and effective, these next-generation flu vaccines could replace current seasonal options by providing protection against more strains that current vaccines cannot adequately cover
    .

    A study published March 24 in the journal Nature details how new flu vaccines are designed and how they protect mice, ferrets and non-human primates
    .

    The work was led by researchers at the University of Washington School of Medicine and members of the Center for Vaccine Research at the National Institute of Allergy and Infectious Diseases, part of the National Institutes of Health
    .

    An estimated 290,000 to 650,000 people have now died from the flu virus
    .
    Existing flu vaccines require seasonal use and generally do not protect against multiple circulating flu strains

    .
    "Most flu vaccines are now quadrivalent, which means they are made from four different flu strains

    .
    The World Health Organization predicts the four most prevalent flu strains each year, but those predictions may be more or less That

    's why we often get 'mismatched' flu vaccines that still work, but only partially," said Daniel Ellis, a research scientist in the lab of Neil King, assistant professor of biochemistry at the UW School of Medicine.

    .

    To create an improved version of the flu vaccine, the team attached the hemagglutinin proteins from four different influenza viruses to custom-made nanoproteins
    .

    This approach allows unprecedented control over the molecular structure of the resulting vaccine and produces a better immune response than conventional flu vaccines
    .

    The new nanoparticle vaccine contains the same four hemagglutinin proteins as the commercial quadrivalent influenza vaccine and produces the same or better response to the vaccine-matched strain in mice, ferrets and non-human primates as the commercial vaccine , which can neutralize the antibody response
    .

    Nanovaccines (but not commercial vaccines) can also induce protective antibody responses against viruses not included in the vaccine formulation
    .

    "Our vaccine does have a strong response to strain-matched viruses, and we see that additional coverage for mismatched strains can reduce risk during flu season," Ellis said
    .


    refer to:

    Seyhan Boyoglu-Barnum, Daniel Ellis, Rebecca A.
    Gillespie et al, Quadrivalent influenza nanoparticle vaccines induce broad protection, Nature (2021).
    DOI: 10.
    1038/s41586-021-03365-x

    Nature: Nano flu vaccine protects against seasonal flu


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