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Thirty years ago, Arthur Ashkin and his colleagues demonstrated that microscopic objects can be bound and moved by beams of light.
, optical capture has become an incredibly powerful tool for researchers in a wide range of scientific disciplines, targeting everything from biocell clusters to individual atoms.
in the field of biological and biomedical sciences, traditional microscope-based "optical tweezers" have been studied in detail on the behavior of proteins and nucleic acids with physiologically relevant force and positional accuracy.
, however, the optical capture system used for these studies consists of large, complex components of optical and electronic components and typically captures and manipulates only one target object at a time.
years, the progress of nanotechnology and the advance of nano-manufacturing generation industry have stimulated the development of innovative operation technology based on "near field" optical capture technology.
By arranging light through the nano photon wave-conduction structure, multiple target objects can simultaneously be captured, selected and transmitted in parallel on the nano photon structure, bypassing the low-volume limits experienced by traditional microscope-based optical tweezers.
In addition, these chip-scale nano photon capture devices have great potential for integration with other laboratory chip technologies, such as microflow sample transfer systems, to produce mobile, low-cost and user-friendly devices for high-volume, high-precision measurement of individual captured objects.
a new review by WIRES Nanomedicine and Nanobiotechnology, James Baker, Ryan Badman and Michelle Wang from Cornell University highlight advances in nano photon manipulation and measurement, as well as the potential to achieve functionality on these chips in biological research and biomedical applications.
The authors describe simple near-field optical propulsion techniques, and how nano photon capture techniques, such as nano photon residering array traps (nSWAT), are used to manipulate and measure up to 100 optically captured targets by precisely matching traditional microscope-based optical capture systems on coin-sized chips that integrate nano-photons, microflows and microelectronics simultaneously on coin-sized chips.
Although many studies in this young field are still in the stage of developing proof-of-concept, the authors describe how to build a toolbox for creating future end-user devices for accurate, high-volume manipulation and measurements of biometric arrays.
source: Nanophotonic Trapping: Precise Products and Me.