Nanoscale: a new sustained-release microsphere based on cd-mof

MOF (metal organic frameworks) is a new kind of potential drug carrier, which develops rapidly However, most of the existing MOF materials are difficult to be used in medicine due to their limited composition Cyclodextrin metal organic framework (cd-mof) takes γ - cyclodextrin as the organic ligand and potassium ion as the metal center It is self-assembled to form a porous network structure Its specific surface area is up to 1200 M2 · g-1 (as shown in Figure 1) It can be decomposed into cyclodextrin in vivo and has good biological safety Figure 1: single crystal structure, scanning electron microscope and powder X-ray diffraction of cd-mof (source: nanoscale) Figure 2: slow release characteristics and lower cytotoxicity of cd-mof / PAA Composite Microspheres (source: nanoscale) Zhang Jiwen research group of Shanghai Institute of pharmaceutical research, Chinese Academy of Sciences, Professor ruxandra Gref of Paris Sud University, France, Fraser of Northwest University, USA Professor Stoddart's research portfolio took the lead in the research of new dosage forms based on cd-mof medical carrier The composite microspheres of polyacrylic acid (PAA) loaded with drug cd-mof were prepared by CO crystallization of ibuprofen and lansoprazole The composite microspheres were prepared by the method of solid / oil / oil emulsion solvent evaporation The composite microspheres maintained the integrity of porous skeleton structure of cd-mof nanocrystals in the interior of the microspheres Meanwhile, the microspheres had obvious slow-release characteristics and lower cells Toxicity (as shown in Figure 2) is a kind of sustained-release microspheres with new structural characteristics Paper link: http://pubs.rsc.org/en/content/articlelanding/2017/nr/c6nr07593b ා! Divabstract