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Existing studies have shown that aging is a self-control mechanism that limits the excessive proliferation of cells and prevents the development of tumors by implementing stable, long-lasting, and usually irreversible growth arrest.
Some evidence suggests that SASP is essential for tissue repair, wound healing, embryonic development, and immune surveillance to remove senescent cells .
immunity
Although the limited therapeutic effect depends on the specific environment, the negative impact of SASP in advanced cancer far exceeds its beneficial contribution, and ultimately accelerates the development of the disease.
Recently, researchers discovered that histone H3-specific demethylase KDM4 is expressed when human stromal cells age.
In clinical oncology, the up-regulation of KDM4 and the decrease of H3K9/H3K36 methylation are associated with poor survival of prostate cancer patients after chemotherapy.
Epigenetic changes in the lysine sites of histone H3 during cell senescence
Epigenetic changes in histone H3 lysine sites during cell senescence .Selective targeting of KDM4 can inhibit SASP of senescent stromal cells Selective targeting of KDM4 can inhibit SASP of senescent stromal cells
This study supports the dynamic changes of H3K9/H3K36 methylation during aging, determines an abnormally tolerable chromatin state, and unveils KDM4 as a key regulator of SASP.
In conclusion, the study uses KDM4 as the target and proposes a new therapeutic approach to manipulate cellular senescence and limit its contribution to age-related diseases including cancer .
With KDM4 as the target, a new therapeutic approach is proposed to manipulate cell senescence and limit its contribution to age-related diseases including cancer.
Original source:
Original source:Boyi Zhanget al.
Boyi Zhang et al.
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