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Breast cancer is one of the most common cancers among women in the world, with 2.
1 million new cases and 627,000 deaths in 2018
.
Studies have shown that genetic factors have a significant contribution to the risk of breast cancer, but the related molecular mechanisms have not yet been fully elucidated
Breast cancer is one of the most common cancers among women in the world, with 2.
Previous studies have shown that genome-wide association studies ( GWAS ) have successfully identified about 200 genetic mutation risk sites with low penetrance that are common in the disease
.
These identified risk sites also provide clues to the mechanisms related to the occurrence and development of breast cancer
Genome-wide Association Study ( GWAS ) has successfully identified about 200 genetic mutation risk sites with low penetrance that are common in the disease
The results showed that the cross-ethnic approach identified four overall breast cancer risk sites (1p13.
3, 5q31.
1, 15q24, and 15q26.
This cross-ethnic approach identified four overall breast cancer risk sites (1p13.
Interracial meta-analysis discovers new breast cancer risk sites
Interracial meta-analysis discovers new breast cancer risk sitesAll in all, the results of the study revealed that there is a consistent association between breast cancer risk sites in African and European populations
.
The study also shows that cross-ethnic analysis can help improve the understanding of breast cancer genetics and identify related causal variants
Cross-ethnic analysis helps to improve the understanding of breast cancer genetics and identify related causal variants
Cross-ancestry GWAS meta-analysis identifies six breast cancer loci in African and European ancestry women.
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