Nat Commun: Depleting B cells can reverse the progression of Alzheimer's disease

Alzheimer's disease (AD) is a progressive neurodegenerative disease that mainly affects the elderly.

Microgliosis and neuronal death exist in mice with hereditary TGFβ deficiency.

Consistent with the positive correlation between AD risk and aging, when systemic inflammation increases, the progression of the disease also depends on peripheral inflammation and the activation of innate immune cells.

The main products of B cells, non-specific immunoglobulin and Aβ specific antibodies can provide neuroprotection.

Currently, the function of B cells in Alzheimer's disease (AD) is not fully understood.

Recently, researchers have discovered that AD is related to the accumulation of activated B cells in the circulation, as well as the infiltration of B cells into the brain parenchyma, leading to the deposition of immunoglobulin around Aβ plaques.

Loss of B cells can reduce the burden of Aβ plaques and microglial activation in the hippocampus of AD mice

Original source:

Ki Kim et al.