Nat Commun: Don't move and lose weight? Fat-burning molecules were found.

Obesity is a health problem that affects more than 40 percent of U.Sadults and 13 percent of the global populationAnti-obesity treatments, including diet, exercise, surgery and medication, have so far failed to reverse the incidence of obesityhere, the researchers used a drug treatment for obesity that reduces heat efficiency through mitochondrial decouplingresearchers show that a recently discovered mitochondrial hydtagine BAM15 is available orally bioavailability and increases the oxidation of nutrients and reduces the body fat quality without changing biochemical and hemological markers of food intake, lean weight, body temperature or toxicityBAM15 reduces liver fat, reduces inflammatory lipids, and has a strong antioxidant effectStudies of hyperinsulinemia-blood glucose clamps have shown that BAM15 can improve insulin sensitivity in a variety of tissue typesthese data together show that BAM15's pharmacological mitochondrial decoupleing effects have a powerful anti-obesity and insulin hypersensitivity effect without affecting muscle mass or affecting food intake