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Alzheimer's disease (AD) is an age-related neurodegenerative disease, the main cause of dementia, and one of the world's major public health problems
Alzheimer's disease (AD) is an age-related neurodegenerative disease, the main cause of dementia, and one of the world's major public health problems
Compared with genome-wide association studies ( GWAS ), there are relatively few studies on AD-related epigenetic changes in the human brain.
GWAS
Previous studies have shown that multiple array-based whole epigenome association studies (EWAS) have identified strong brain methylation changes in AD; however, array-based detection can only detect about 2% of all CpG sites in the genome
Multiple array-based whole epigenome association studies (EWAS) have identified strong brain methylation changes in AD; however, array-based detection can only detect about 2% of all CpG sites in the genome
Overview of EWASplus method
Overview of EWASplus methodIn this study, the researchers constructed the EWASplus method, a computational method that uses a supervised machine learning strategy (ML) to extend the coverage of EWAS to the entire genome
The researchers constructed the EWASplus method, which is a computational method that uses supervised machine learning strategies (ML) to extend the coverage of EWAS to the entire genome
Summary of EWASplus results
Summary of EWASplus resultsEWASplus also performed well on data collected from independent cohorts and different brain regions
A machine learning approach to brain epigenetic analysis reveals kinases associated with Alzheimer's disease.
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