People with type 2 diabetes tend to have worse muscle function than others.
In type 2 diabetes, the ability to produce insulin is affected.
The patient's blood sugar increases for a long time, the muscles have poor ability to absorb sugar from food, and the muscle function and strength of patients with type 2 diabetes are impaired.
Recently, a research team from Lund University in Sweden discovered that in patients with type 2 diabetes, a specific gene is very important for the ability of muscle stem cells to create new mature muscle cells.
The research results were published in "Nature Communications".
In this study, the researchers divided type 2 diabetes patients and normal people into two groups.
Under exactly the same conditions, they extracted mature muscle cells and compared them.
At the same time, they compared the muscle cells of the two groups before and after differentiation.
The analysis identified a total of 20 genes, including VPS39, whose gene expression is in different groups in immature muscle stem cells and mature muscle cells.
Research and analysis found that although the muscle stem cells of the two groups were grown under the same conditions, the epigenetic changes in the type 2 diabetes group during the differentiation from muscle stem cells to mature muscle cells were twice that of the type 2 diabetes group the above.
Muscle-specific genes are not normally regulated, and epigenetics does not play the same role in the cells of type 2 diabetic patients.
Differential gene expression in myoblasts and myotubes between type 2 diabetic patients and normal people, and identified VPS 39 as a regulator of human myogenesis.
To confirm this finding, the researchers also used V.
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