Nat Commun: HIF-1 alpha and HIF-2 alpha play the opposite regulatory role in renal transparent cell carcinoma.

In 2018, there will be more than 400,000 new cases of kidney cancer worldwide, and renal transparent cell carcinoma (ccRCC) accounts for 70-80% of all kidney cancers.
In most ccRCC patients, the genetic event of double-equal incasion of the cancer-suppressing gene associated with Von Hippel-Lindau (with Hibbert-Lindau syndrome) indicates that the absence of one or more of the pVHL protein subsypes with anti-cancer function is critical to the early on oncology of tumors.
previous studies have shown that pVHL's characteristic anti-cancer effects are achieved primarily by targeting HIF-1 alpha and HIF-2 alpha and promoting protein hydrolysing of both oxygen-dependent ubilin-mediated proteins.
and the mutation infestion of VHL is caused by the accumulation of two transcription factors, HIF-1 alpha and HIF-2 alpha.
Although studies on ccRCC have shown that HIF-1 alpha is an inhibitor of invasive tumor behavior and HIF-2 alpha has a promoting effect, it is not clear what role the two play in tumor development.
the study, the researchers used an in-body ccRCC model in which Hif1a was essential for tumor formation, while the absence of Hif2a had less impact on tumor development.
researchers found that HIF-1 alpha and HIF-2 alpha are necessary for the esopaedals of transparent cells.
transcriptometology and proteomics analysis showed that HIF-1 alpha was able to regulate the glycolysis process, while HIF-2 alpha was involved in the regulation of lipoprotein metabolism-related genes, the biogenetic occurrence of ucoseos, and the transcriptional activity of E2F and MYC.
-2 alpha-defective tumors showed an increase in antigen delivery, interferon signal activation, and CD8-T cell immersion and activation.
loss of single copies of HIF1A and high expression levels of HIF2A mRNA have also been shown to be associated with changes in the immune micro-environment in human ccRCC.
results revealed the carcinogenic effects of HIF-1 alpha in renal transparent cell carcinoma, and changes in the active balance of HIF-1 alpha and HIF-2 alpha affected the biological differences and disease invasiveness of cCRCC.
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