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    Home > Biochemistry News > Natural Products News > Nat commun: high fat diet leads to diabetes, intestinal microbes or the culprit

    Nat commun: high fat diet leads to diabetes, intestinal microbes or the culprit

    • Last Update: 2019-08-16
    • Source: Internet
    • Author: User
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    August 16, 2019 / BIOON / - researchers found that our dietary choices weaken our gut immune system and lead to the development of diabetes More and more studies show that during obesity, our immune system often responds to bacterial components that "leak" through intestinal tissue and cause inflammation In turn, inflammation leads to insulin resistance, which makes people prone to diabetes In a new study recently published in nature communications, Dr Dan winer of the Toronto General Hospital Institute and the University of pathology Health Network (UHN) and his team emphasized how a high-fat diet affects B cells in the gut immune system, especially those that produce a protein called IgA Photo source: Helen luck, lead author of nature Communications Research Report, said: "we found that during obesity, there is a low level of B cells in the gut, which can produce an antibody called IgA IgA is naturally produced by our bodies and is essential for regulating the bacteria in our gut It serves as a defense mechanism to help neutralize potentially dangerous bacteria that take advantage of environmental changes, such as when we eat unbalanced or fatty foods "In their experiments, they also observed that preclinical models lacking IgA (i.e., unprotected IGA) worsened blood glucose levels when fed high-fat foods In addition, transplanting intestinal bacteria from these IgA deficient models into those without intestinal bacteria can lead to disease, which indicates that IGA can regulate the number of harmful bacteria in the gut during diet related obesity In collaboration with the UHN weight-loss surgery research team led by Dr johane Allard and Dr Herbert Gaisano, the team found that shortly after weight-loss surgery, the level of IgA in the feces of patients would rise, indicating the importance of IgA and the gut immune system for obese patients In general, the study highlights the strong link between a high-fat diet, obesity, and a lack of intestinal IgA in promoting inflammation and insulin resistance Understanding that these antibodies can regulate pathogens, prevent "intestinal leakage" and other obesity complications is a powerful tool against diabetes "If we can enhance these IgA B cells or their products, then maybe we can control the type of bacteria in the gut," Dr Dan winer said "Especially those diseases that are more likely to be associated with inflammation and eventually insulin resistance Looking forward to the future, this work may lay the foundation for new intestinal immune biomarkers or the treatment of obesity and its complications, such as insulin resistance and type 2 diabetes "Reference: Daniel A winer et al Got associated IgA + immune cells regular objective related insulin resistance, nature communications (2019) Doi: 10.1038/s41467-019-11370-y
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