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Some studies have shown that the gut microbiome alters the metabolism of intestinal vitamin D (VDM), and probiotic supplements can affect circulating vitamin D levels.
These findings have significant clinical benefits, as several large epidemiological studies have shown that people with low serum vitamin D levels increase the risk of a variety of adverse health outcomes, including osteoporosis, obesity, inflammatory bowel disease, occasional diabetes, cardiovascular disease, cancer, and autoimmune diseases.
While some studies have linked low levels of hydroxyvitamin D (25(OH)D:25-hydroxyvitamin D3 and 25-hydroxyvitamin D2 to disease, others, such as previous studies in MrOS studies, have shown no significant association with diseases such as cardiovascular disease or occasional diabetes.
recent large randomized controlled trial of vitamin D supplementation in more than 25,000 adults showed that vitamin D supplementation was not beneficial in preventing cardiovascular events or cancer.
vitamin D is highly expressed in the gastrointestinal tract, where gene expression is transducted.
currently has limited understanding of the interactions between the gut microbiome and vitamin D.
recently, researchers published a paper in the journal Nature Communications, which cross-sectionally analyzed 567 elderly men, quantified serum vitamin D metabolites using LC-MSMS, and defined fecal suboperation classification units from 16S RNA gene sequencing data.
system developmental diversity and non-redundant covariate analysis of Faith showed that serum levels of 1,25 (OH) 2D could explain a 5% variation in α-diversity.
1,25 (OH)2D was the strongest factor in the analysis of β diversity using unstated UniFrac, explaining the 2% variation.
random forest analysis identified 12 groups, 11 of which were in the Firmicutes gate, 8 of which were positively associated with 1,25 (OH) 2D and/or hormone-hormone prebiosomes .
men had higher levels of 1,25 (OH) 2D and a higher activity ratio, but 25 (OH) D was not high in itself and was more likely to have butytate-producing bacteria associated with better intestinal microbial health.
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