Nat Commun: Identification of new gene constellations associated with systemic lupus erythematosus and genetic heterogeneity analysis of ancestral groups

Systemic lupus erythematosus (SLE) is a highly hereditary autoimmune disease characterized by the production of autoantibodies and multi-organ damage.
genetic factors play a crucial role in the disease, with differences in prevalence, severity and age of onset among patients from different ancestral groups.
genetic research in the past is more concentrated in the European population.
the genetic differences in SLE in different ancestral groups have not been well clarified.
The Manhattan map reveals a link between systemic lupus erythematosus (SLE) in Chinese and European populations, and to address these problems, the study conducted genome-wide association analysis, increasing the sample size of Chinese groups to existing European studies.
results showed that the researchers identified 38 new SLE-related gene constellations and incompletely shared genetic structures.
further studies showed that, in addition to the human le white blood cell antigen (HLA) region, nine other pathogenic points showed significant ancestral group differences and revealed that the production of antibodies was a potential mechanism for differences in disease performance.
the multigene risk score performed better when trained against data sets matched by pedigree.
a total of aggregate statistics from different ancestral groups analyzed by the Multigene Risk Score (PRS), the above analysis helps to reveal the genetic basis for SLE differences in ancestral groups.