Nat Commun: In Alzheimer's disease, tau protein can be transmitted through AC neurons

Tau protein is an iconic pathology of Alzheimer's disease, and existing animal models have shown that tau, promoted by beta-amyloid (A-beta), spreads from one cell to another through neuronal connectionsrecently, researchers used the Epidemiological Spread Model (ESM) to test this hypothesis in humans, simulating tau transmission and comparing these simulations with observational patterns measured using tau-PET in 312 Alzheimer's patientsvariation of up to 70% of tau's overall spatial pattern can be explained by the modelSurprisingly, ESM can predict the spatial pattern of tau, regardless of the presence of Beta in the brain, but the area with greater aerofane display edatau shows more tau than the connection pattern predicts, indicating the role of A-beta in accelerating tau diffusionoverall, the findings provide human evidence that tau travels through the neuronal communication pathways even in normal aging, and that the process is accelerated by the presence of brain Beta