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Gut microbes are involved in the digestion and degradation of nutrients, maintaining the integrity of the digestive tract, stimulating the host immune system and regulating host metabolism.
recent years, the relationship between gut microbes and certain diseases, including diabetes, cardiovascular disease, obesity and chronic gastrointestinal diseases such as inflammatory bowel disease, has been confirmed.
most of the factors associated with human diseases are reduced microbial diversity, changes in microbial composition, and certain microbial abundances and paths.
, however, the gut microbiome is a complex ecosystem through which microorganisms can exchange or compete for nutrients, signaling molecules, or immune escapism mechanisms through complex ecological interactions.
, the interaction between these microorganisms is the focus of research.
The study constructed and compared 2,379 genomes from four human queues in the Netherlands, including inflammatory bowel disease (IBD) cohorts, obesity cohorts, and two population-based cohorts.
study found that 38.6% of microbial species abundance and 64.3% pathogenic co-abundance varied significantly between the queues, of which 113 strain abundance and 1050 pathprenity showed IBD cohort-specific effects and 281 pathpynological abundances showed obesity-specific effects.
found three strains and four paths in IBD, as well as one path in 300 obesity-related pathogens, which play a key role in disease-specific co-abundance networks.
In obesity, the allantoinity path is a key path, and obesity-specific co-abundance is associated with 85 paths, mainly with biosynthesis of acetyl acetate/winter amino acid, and with insulin secretion and glucose metabolism.
study is based on meta-genome sequencing for microbial network analysis to detect microbial species and functional paths.
of enteric microorganisms can be assessed by changes in abundance levels and levels of microbial interaction.
IBD and obesity-specific strains and pathogens may play an important role in regulating microbial ecosystems in diseases, and these disease-specific microbial interactions extend current understanding of the role of microbiomes in disease.
source: Lianmin Chen, Gut microbial co-abundance networks show specificity in andrea bowel disease and obesity, Nature communication, 2020, 11:4018 Source: Network !-- Content Show Ends - !-- Determines whether the login ends.