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Nat Commun: Intestinal microbial metabolite short-chain fatty acids improve cancer adoptive immunotherapy

 Last Update: 2021-08-02
 Source: Internet
 Author: User

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The gut microbiota has been proven to directly affect the efficacy of specific cancer immunotherapy

The latest research shows that the activity of immune cells can be regulated by microbial molecules

In this study, the researchers found that SCFA valeric acid and butyric acid can enhance the anti-tumor activity of CTL cells and CAR-T cells (chimeric antigen receptor T cells) through metabolism and epigenetic reprogramming

SCFA valeric acid and butyric acid can enhance the anti-tumor activity of CTL cells and CAR-T cells (chimeric antigen receptor T cells) through metabolism and epigenetic reprogramming

Microbial-derived SCFAs promote the production of effector cytokines in CTL

The results show that in vitro treatment of CTL and CAR-T cells with valeric acid and butyric acid can increase the function of mTOR as a central cell metabolism sensor and inhibit the activity of class I histone deacetylase

Further studies have shown that this reprogramming effect will lead to the increase of effector molecules such as CD25, IFN-γ and TNF-α, and significantly enhance antigen-specific CTL and CAR-T targeting ROR1 in mouse models of melanoma and pancreatic cancer .

This reprogramming action will lead to the increase of effector molecules such as CD25, IFN-γ and TNF-α, and significantly enhance the anti-tumor activity of antigen-specific CTL and CAR-T cells targeting ROR1 in mouse models of melanoma and pancreatic cancer

Valeric acid can enhance CAR-T cell function

All in all, the study identified valeric acid and butyric acid as two SCFA metabolites with therapeutic effects in cancer immunotherapy

The study identified valeric acid and butyric acid as two SCFA metabolites with therapeutic effects in cancer immunotherapy

Microbial short-chain fatty acids modulate CD8+ T cell responses and improve adoptive immunotherapy for cancer.

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