Nat Commun: Intestinal microbiome disorder sifts human spongiform hemangioma?

Spongiform hemangioma (CA) is a common vascular abnormality that causes cerebral hemorrhageIn mouse-based studies, the role of gram-negative bacteria and changes in intestinal balance in CA pathogenesis has been reportedExperimental studies have also shown potential microbial group differences between non-CA and CA individuals in gene sequencing based on 16S rRNArecently, researchers assessed microbiome differences in a larger human queue, including subjects with CA and CA-free, and subjects with different clinical characteristicsThe researchers also used metagenome sequencing for more definitive microbiome analysisin CA patients, researchers found relative abundance of different bacterial species, consistent with the presumed allowable microbiome that drives CA lesions through lipid polysaccharide signalsDifferences in other microbiomes are associated with CA clinical behaviorThe weighted combination of microbiotic signals and plasma inflammatory biomarkers enhanced the association with disease severity and bleedingthis is the first time researchers have demonstrated the sensitivity and specificity of the diagnostic microbiome in human neurovascular disease