Obesity is a serious health threat worldwide, and the incidence of obesity and metabolic syndrome has risen to epidemic levels over the past three decades, especially in Western countries.
obesity and its associated metabolic disorders are type 2 diabetes, heart and kidney disease, and risk factors for at least 13 types of cancer, including post-menovascular breast cancer, colorectal cancer, endometrial cancer, esophageal adenocarcinoma and gallbladder cancer.
recent studies have shown a strong association between obesity and breast cancer.
previous studies have shown that calorie restriction can improve the harmful metabolic effects associated with obesity and inhibit cancer progression, but this intervention is difficult to implement and sustain outside the clinic.
a recent study published in Nature Communications, researchers tested time-limited feeding (TRF) in models of obesity-driven post menotinal breast cancer mice.
study showed that TRF inhibited the growth of obesity-enhanced breast tumors in both models without limiting calories or losing weight.
TRF can also reduce the metastasis of breast cancer to the lungs.
, in tumor gene model mice, TRF can delay tumor occurrence before obesity occurs.
notable, TRF increases the sensitivity of insulin throughout the body, reduces high insulinemia, restores the circadian gene expression rhythm of tumors, and reduces tumor growth and insulin signaling.
important, inhibiting insulin secretion with nitrosazole simulates TRF, while artificially raising insulin through an insulin pump can reverse the effects of TRF, which works by regulating high insulinemia.
, these data suggest that TRF may be effective in the prevention and treatment of breast cancer.