NAT COMMUN: Mitochondria control angiogenesis during wound healing and tumor growth.

Vascular is a highly malleable tissue that can switch from a stationary state to an active proliferative state during angiogenesisIn this process, metabolic reprogramming of endothelial cells () is essential to meet the increasing cellular energy needs under growth conditionsHere, the researchers assessed the effect of mitochondrial biology on newborn blood vessels and provided a model for vascular restricted breathing deficiencies by specifically removing genes that encode cytochrome oxidase () assembly factors in miceResearchers have shown that specific knockout causes vascular developmental defects that cause embryo deathInducing specific gene deletion in adult mice does not produce significant phenotypesHowever, the loss of angiogenesis in the case of energy needs is severely impaired by significantly delayed wound healing and impaired tumor growthIn summary, this study provides genetic evidence for the need for mitochondrial respiration of vascular endothelial cells during the development, tissue repair and cancer of new blood vessels