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Brain tumors are the main cause of childhood cancer-related morbidity and mortality
Child diagnosis
Existing genome-wide analysis studies have changed our understanding of pHGGs and clarified different molecular characteristics compared with adult HGG, including the close relationship between tumor location, patient age and recurrent mutations, indicating the pathogenesis and developmental background of pHGG There is a close connection between
In 2016, the World Health Organization's Central Nervous System Tumor Classification (CNS) included molecular-based criteria and defined diffuse midline glioma-H3K27M mutant (DMG-K27M) as a unique diagnostic entity
H3K27M mutations most commonly occur in 2 of the 15 genes encoding histone H3, of which H3F3A encodes H3.
In vitro and in vivo disease models that reflect the close connection between the developmental background and pathogenesis of pHGG are essential to promote understanding and identify treatment loopholes
The results showed that these models reproduced the histopathology, DNA methylation characteristics, mutations, and gene expression patterns of the patient's tumors from which they were derived , and included rare subgroups that are not well represented by existing models
Reproduced the histopathology, DNA methylation characteristics, mutations and gene expression patterns of the patient tumors from which they were derived.
The genomic profile of PDOX and cell lines retains matching changes that exist in the patient’s tumor and represents various pHGG subtypes
The genomic profile of PDOX and cell lines retains matching changes that exist in the patient’s tumor and represents various pHGG subtypes
Predicted different responses to PI3K/mTOR and MEK pathway inhibitors in vivo Predicted different responses to PI3K/mTOR and MEK pathway inhibitors in vivo
These unique new models and online interactive data used to explore relevant detailed molecular characteristics and HTS chemosensitivity data provide a wealth of resources for pediatric brain tumor research
Original source:
Original source:Chen He et al.
Chen He et al.
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