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Nat Commun: Predicting Clostridium difficile infection based on microbiota markers

 Last Update: 2021-04-22
 Source: Internet
 Author: User

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antibiotic resistance mechanisms

bacterial lung infection

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Clostridium difficile is the most common cause of antibiotic- associated infectious diarrhea (AAD), and it is also the pathogen that causes the most medical-related infections worldwide.

Antibiotic infection

However, currently there is a lack of markers for predicting the development of CDI or AAD.

prevention

The gut microbiota of patients with CDI and other forms of AAD is destroyed , which is characterized by decreased diversity and increased levels of enterococci .

The gut microbiota of CDI patients and other forms of AAD patients is destroyed.

CDI patients have shown a significant reduction in microbial diversity before receiving antibiotic treatment CDI patients have shown a significant reduction in microbial diversity before receiving antibiotic treatment

Flow chart of patients and samples under study

The researchers also found that the flora imbalance caused by antibiotic treatment is class-specific, and β-lactam drugs further increase the abundance of enterococci.

Bacterial imbalance caused by antibiotic treatment is class-specific .

The results of the study were validated in an independent CDI prospective patient cohort.

Original source:

Matilda Berkell et al.

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