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Nat Commun: T cell receptor pool of tumor-infiltrating T cells can predict the prognosis of cancer patients

 Last Update: 2021-08-02
 Source: Internet
 Author: User

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PD1 (programmed death receptor 1) immune checkpoint blockade (CPB) therapy is increasingly used to treat metastatic solid tumors, and the response rate of patients is 20-55%

However, it is still a big problem to identify patients who

There is an urgent need to identify predictive biomarkers of patient care to identify patients with metastatic cancer that respond better to CPB

Previous studies have shown that tumor infiltration of T cells is essential for an effective anti-cancer immune response

TIL/Tc TCR can predict patient's overall survival rate and response to PD1 CPB

All in all, the results of the study reveal that in various cancers including melanoma, the diversity of TIL/Tc can predict the overall survival (OS) of patients without PD1 blockade, while TIL/Tc before treatment The type of clone can predict the patient's response to anti-PD1 treatment

The results of the study revealed that in various cancers including melanoma, the diversity of TIL/Tc can predict the overall survival (OS) of patients without PD1 blockade, and the clone of TIL/Tc before treatment Type can predict the patient's response to anti-PD1 treatment

The T cell receptor repertoire of tumor infiltrating T cells is predictive and prognostic for cancer survival.

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