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    Home > Active Ingredient News > Infection > Nat Commun: Targeting Gα13-mediated integrin signaling can effectively improve systemic inflammation

    Nat Commun: Targeting Gα13-mediated integrin signaling can effectively improve systemic inflammation

    • Last Update: 2021-05-31
    • Source: Internet
    • Author: User
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    Bacterial infection (such as sepsis) or viral infection can cause systemic inflammatory response syndrome.


    Infected blood vessel thrombus

    Inflammation, vascular leakage, and thrombosis can collectively lead to multiple organ dysfunctions, including acute respiratory distress syndrome (ARDS), renal failure, disseminated intravascular coagulation (DIC), and circulatory system failure.


    Inflammation, vascular leakage, and thrombosis can collectively lead to multiple organ dysfunctions, including acute respiratory distress syndrome (ARDS), renal failure, disseminated intravascular coagulation (DIC), and circulatory system failure.



    Therefore, there is an urgent need for new drugs for the treatment of systemic inflammation.




    MB2mP6 inhibits the interaction of Gα13 and β3 integrin and the function of platelets

    MB2mP6 inhibits the interaction of Gα13 and β3 integrin and the function of platelets

    In this study, the researchers found that in white blood cells and platelets, the use of MB2mP6 nanoparticles targeting Gα13-mediated integrin signals can inhibit inflammation and thrombosis without causing vascular leakage/bleeding.


    The use of MB2mP6 nanoparticles targeting Gα13-mediated integrin signals can inhibit inflammation and thrombosis without causing vascular leakage/bleeding.



    MB2mP6 can inhibit pulmonary vascular leakage

    MB2mP6 can inhibit pulmonary vascular leakage

    All in all, the results of the study show that inflammation and thrombotic events can independently lead to poor prognosis and aggravate systemic inflammation.


    The results of the study show that inflammation and thrombotic events can independently lead to poor prognosis and aggravate systemic inflammation.



    org/10.




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