Nat Commun: The immune evolution process from pre-tumor formation to invasive lung adenocarcinoma and its potential molecular characteristics

Although encouraging progress has been made in clinical treatment, lung cancer is still one of the leading causes of cancer-related deaths worldwide, mainly caused by incurable late diagnosis .

Computer tomography (CT) -guided lung cancer screening has reduced the mortality rate of lung cancer by 26-61%, which emphasizes the necessity of early detection and intervention of the disease to reduce the incidence and mortality of lung cancer.

At present, about the anti-cancer immune -related effects of early molecular mechanisms of carcinogenesis force ADC is unclear.

IPN immune landscape at different stages and its related genomic and epigenome characteristics

The results show that in the continuous process from the formation of lung cancer to pre-invasive lesion ADC, minimally invasive ADC, and invasive ADC, the immune response of anti-cancer immunity gradually decreases, and the intensity of this regulation gradually increases, including the down-regulation of immune activation signals and immune response.

The immune landscape from preneoplastic lesions to aggressive lung adenocarcinoma

All in all, the results of the study show that treatments targeting the immune microenvironment of patients with lung cancer precursors can prevent the development of aggressive lung cancer.