Nat Commun: The Team at Peking University, in association with the U.S. National Cancer Institute, found that FAM3D is a necessary condition for protecting against inflammation-causing tumors

Inflammatory bowel disease (IBD) is a complex multifamily disease, including Crohn's disease and ulcerative colitis (UC), both characterized by chronic relapse inflammation and endothor damage, and associated with an increased risk of colorectal cancer.
UC is a major form of IBD, the cause of which is still unclear.
growing evidence that impaired function of the colon mucous membrane barrier is a key factor in UC's onset.
balance of the mucous membrane barrier is maintained by genetic and environmental factors, and its damage is one of the pathogenesis of diseases such as inflammatory bowel disease.
a cytokine-like molecule, FAM3D (Fam3D in mice), was highly expressed in the gastrointestinal tract of mice.
Recently, researchers in China have documented that the absence of Fam3D is associated with impaired integrity of the colon mucous membranes, increased epithelial growth, reduced production of antimicrobial peptides, and increased sensitivity to chemically induced colitis, and is associated with a high incidence of cancer.
Pre-treatment of Fam3D-/- mice with antibiotics significantly reduced the severity of chemically induced colitis, and the wild type (WT) mice living with Fam3D-/- mice showed a decrease in sensitivity to colitis and a skewed composition of the fecal microbiome.
the initial balance of the WT and Fam3D-/- mouse microbiomes, but the bacterial composition was increasingly differentiated after separation.
results show that Fam3D plays an important role in colon stabilization, prevention of inflammatory-related cancers, and normal microbiome composition.