Nat Commun: UV radiation induces the degradation of collagen and inhibits the invasion of melanoma

Ultraviolet radiation (UVR) is a major environmental risk factor for the occurrence and development of melanoma, and exposure to sunlight is the main cause of increased disease incidence
.

Ultraviolet radiation (UVR) is a major environmental risk factor for the occurrence and development of melanoma, and exposure to sunlight is the main cause of increased disease incidence
.

Ultraviolet radiation (UVR) is a major environmental risk factor for the occurrence and development of melanoma, and exposure to sunlight is the main cause of increased disease incidence

Although the correlation between UVR and the incidence of melanoma has been fully confirmed, the correlation between sun exposure or sun damage to the skin and the survival rate of melanoma patients is still controversial
.

Previous studies have shown that the amount of collagen in the extracellular matrix (ECM) changes the behavior of melanoma cells
.

Surprisingly, both the increase and decrease of collagen deposition are related to the malignant behavior of tumors

Both the increase and decrease of collagen deposition are related to the malignant behavior of tumors

UVR-driven mutations are associated with ECM degradation and collagenase expression

UVR-driven mutations are associated with ECM degradation and collagenase expression

On the contrary, inhibiting the degradation of ECM and the expression level of MMP1 can restore the invasion ability of melanoma
.

Researchers found that elderly patients with primary cutaneous melanoma showed more cancer cell invasiveness , because the frontier single cells related to the invasiveness of melanoma expressed and deposited more collagen, so collagen and single melanin The invasion ability of tumor cells is a powerful predictor of the specific poor prognosis of melanoma

Elderly patients with primary skin melanoma show more cancer cell invasiveness.
Elderly patients with primary skin melanoma show more cancer cell invasiveness.

Low collagen levels in elderly patients are associated with low invasiveness and improved prognosis

Low collagen levels in elderly patients are associated with low invasiveness and improved prognosis

All in all, the results of the study revealed that the high expression level of COL1A1 is a biomarker related to poor prognosis in a series of primary cancers
.

The high expression level of COL1A1 is a biomarker related to poor prognosis of a series of primary cancers
.

The high expression level of COL1A1 is a biomarker related to poor prognosis of a series of primary cancers

Ultraviolet light-induced collagen degradation inhibits melanoma invasion.

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