Nat. Commun.: Yu Biao group and Wang Ning group made important progress in research and development of anticancer molecules

Most cancer patients are ultimately fatal due to cancer cell metastasis and diffusion, but how to inhibit cancer cell metastasis or control cancer cells that have already metastasized is still an unsolved problem In recent years, Wang Ning and others have developed an innovative method of selective separation of tumor regenerating cells, and found that these cancer cells have a strong ability of metastasis, but also have a strong drug resistance, which can not be killed by existing anti-cancer drugs Since 2014, through multiple rounds of screening, synthesis and optimization, Wang Ning team and Yu Biao team have found a kind of targeted molecules with significant effect on the proliferation and metastasis of regenerative cells of TRC in vitro and in vivo The optimized molecule wyc-209 can inhibit the proliferation and induce apoptosis of regenerating cells of lung cancer, breast cancer, ovarian cancer, melanoma and other malignant tumors in vitro at low concentration In the mouse experiment, the molecule can effectively inhibit the metastasis of cancer cells, and kill the metastasis of cancer cells, the effective rate is nearly 90% In comparison with the same type of drugs already on the market, wyc-209 not only has superior efficacy, but also has no side effects In the study of the mechanism of action, the molecule has been proved to be an effective activator of retinoic acid receptor, and it can induce cancer cell apoptosis through caspase 3 signal pathway These antitumor molecules have applied for Chinese patent and international patent before publication The research progress was completed by Yu Biao, State Key Laboratory of life organic chemistry, Shanghai Institute of organic chemistry, Chinese Academy of Sciences, and Wang Ning, School of life science and technology, Huazhong University of science and technology It was recently published online in nature communications (DOI: 10.1038 / s41467-018-03877-7) The first authors of this paper are Dr Chen Junwei from the school of life, Huazhong University of science and technology and Dr Cao Xin from Shanghai Institute of organic science, Chinese Academy of Sciences; Professor Wang Ning and researcher Yu Biao are co senior correspondents The research of this project is supported by Huazhong University of science and technology, Chinese Academy of Sciences and Foundation Committee Corresponding author: Professor Wang Ning, researcher Yu Biao