Nat Commun:IL6 Trans-Signal Transductive Path: The Potential Mechanism for Diffuse Cancer Cell Metastasis.

In breast cancer, tumor cells move to the far end six to eight years earlier than the clinical manifestations of metastasis.
although thousands of breast cancer cells spread and return to the bone marrow before the initial surgery, less than a small percentage usually succeed in establishing a significant metastasis in a few months to a few years.
In order to determine the relevant signals that support patient survival or tumor growth, the researchers analyzed the rare bone marrow-based diffuse cancer cells (DCC) at a longer time before the on-the-emergence of the metastasis and identified the IL6/PI3K signaling pathrail as a candidate path path for DCC activation.
, similar to breast epithelial cells, DCC cells lack the expression of cell membrane IL6 receptors.
and mechanism studies have shown that the IL6 trans-signal transducting path is able to regulate the dry state of the mammary epithal cells through gp130.
IL6 signaling pathline activated in breast stem cells Researchers found that the IL6 trans-signal transducting pathline responds to stem cell micro-environmental (niche) dependence, as opposed to vascular micro-environment cells, which reduce the expression of gp130 in bone marrow stem and endoblast cells in pre-deterioration mammary epithelial cells.
cells activated by PIC3CA are independent of the IL6 transverse signal transducting path.
researchers found that, consistent with the bottleneck function of micro-environmental DCC cells, PIK3CA mutations were highly associated with late metastasis cells, which were extremely rare in early DCC.
IL6 signaling path path in BM-DCCs in breast cancer patients was activated, the study revealed that the initial formation of tumor metastasis is usually not cancer cell autonomy, but depends on micro-environmental-related signals.
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