Nat Genet: A genome-wide association analysis of 100,000 plus cases identified 86 new prostate cancer susceptible mutations

Prostate cancer is a highly endexual disease that varies widely from ancestral group to ancestral group, with African Americans about 75 percent more likely than non-Hispanic whites and 45 percent fewer Asians.
age, family history of prostate cancer, and embryo variants are all known risk factors for prostate cancer, with genetic factors contributing up to 57% of prostate cancer risk.
, there is speculation that genetic factors may have contributed to some differences in the incidence of prostate cancer.
In this study, researchers consolidated genome-wide association analysis (GWAS) data from 107,247 cases of prostate cancer and 127,006 controls (from Europe, Africa, East Asia and Spain) to identify common genetic variants associated with disease risk in populations.
subjects' basic characteristics were analyzed by multiple ancestors, and the researchers identified 86 new genetic risk variants associated with independent prostate cancer risk, bringing the total number of known risk variants to 269.
The absolute genetic risk score (GRS) for prostate cancer was very high for individuals of different ethnic groups with very high GRS, which was associated with a higher risk of prostate cancer in men of different bloodlines, and for European men with the highest GRS very high digits. The risk was 5.06 times higher for men of the same ethnicity (95% CI 4.84-5.29) and 3.74 times for men of African descent (3.36-4.17).
estimated that the average GRS for men of African descent is 2.18 times that of men of European descent (95% CI 2.14-2.22), while the average GRS for men of Eastern Asian descent is 0.73 times that of men of European descent (0.71-0.76).
results confirm that embryo genetic variation has a role to play in differences in prostate cancer risk groups, and GRS provides a method for personalizing risk prediction.