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Esophageal cancer is the sixth most common cause of cancer-related death in the world, and esophageal squamous cell carcinoma (ESCC) is the most common subtype
Esophageal cancer is the sixth most common cause of cancer-related death in the world, and esophageal squamous cell carcinoma (ESCC) is the most common subtype
Epidemiological studies have investigated and identified several potential environmental and life>
Previous studies on the mutation process of human cancers and normal tissues have shown that both exogenous mutation exposure and endogenous processes will produce unique mutation patterns, called mutation characteristics
ESCC incidence and related data collection
ESCC incidence and related data collectionIn this study, the researchers analyzed 552 ESCC genomes from eight countries with different disease incidences by combining whole-genome sequencing and mutation signature analysis with cancer epidemiological data, aiming to identify the driving ESCC global incidence rate Factors related to the difference
The researchers combined whole-genome sequencing and mutation signature analysis with cancer epidemiological data to analyze 552 ESCC genomes from eight countries with different disease incidence rates, aiming to identify the relevant factors that drive the global incidence of ESCC
Correlation between ESCC risk factors and mutation characteristics
Correlation between ESCC risk factors and mutation characteristicsThe spectrum of disease-related mutations is similar in all countries studied
Researchers have found that tobacco, alcohol, opium, and germline mutations are associated with specific mutation characteristics and ESCC risk factors, but have little effect on mutation burden
Mutational signatures in esophageal squamous cell carcinoma from eight countries with varying incidence
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