Nat Immunol: There is persistent T-cell immune protection in patients recovering from COVID19.

September 9, 2020 /--- Researchers at the University of Oxford have found that natural infections with COVID-19 produce powerful T-cell responses, including inducing T-cell "memory" to potentially resist future infections, the results of which are published in the journal nature immunology.
Although studies have shown that COVID-19 induces B-cell antibody responses, it is not clear whether COVID-19 causes the immune system to produce virus-specific T-cells, and whether they are important for recovering from initial infections and preventing new infections.
antibodies can identify and destroy pathogenic factors such as viruses and bacteria, while T-cells can target abnormal cells in the body, such as tumor cells or virally infected cells.
T cells also help attract other immune cells to the region.
Professor Dong Tao, head of research at MRC's human immunology department at www.pixabay.com, said: "By studying T-cell immune responses in depth and extensively, we will begin to better understand why some people develop mild diseases and how we can prevent or treat infections.
" T-cells may also last longer than antibodies, so they can provide other ways to diagnose whether someone has ever been infected with COVID-19 after antibody levels drop.
" T cells are attracted by tumor or viral protein fragments (tables) that appear on the surface of diseased cells, acting like flags waving flags at T cells to show them where they are needed.
the study, researchers analyzed blood samples from PATIENT-19 patients to identify peptides containing T-cells, including six immune advantage regions (table clusters) targeted by T-cells in many patients.
identifies the areas of the virus targeted by the immune system, we expect these findings to help determine the role of T-cells in disease outcomes," said Dong.
team compared blood samples from 28 patients with mild and 14 severe COVID-19s with samples from 16 healthy receptors.
Professor Graham Ogg said: "We found that patients with mild COVID-19 had different T-cell response patterns than those with more severe infections, which may help provide new insights into the nature of immune protection.
" Although the team believes that poor T-cell response may lead to persistence of SARS-CoV-2 virus and COVID-19 mortality, recovering patients with mild and severe diseases still have T-cell memory two months after infection.
only a few T-cells need to remember primary infections, and they can replicate to quickly initiate a powerful immune response.
researchers also found that SARS-CoV-2 synth proteins are often identified by T-cells in recovering patients, supporting the methods currently being used in many vaccines being developed, including the Oxford vaccine.
team also found that other parts of the virus, including membranes and nucleoproteins, also cause a strong T-cell immune response and may provide other vaccine targets.
(bioon.com) Source: Persistent immune memory of COVID-19 found in recovered patient T cells Source: undefined undefined et al. Broad and strong memory CD4 plus CD8 plus T cells induced by SARS-CoV-2 in UK convalescent individuals following COVID-19, Nature Immunology (2020). DOI: 10.1038/s41590-020-0782-6.