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Retinitis pigmentosa (RP) is a progressive, hereditary, mostly single-gene blinding disease caused by mutations in more than 71 different genes (https://sph.
Optogenetic vision restoration is a method that is independent of the background of genetic mutations and can be used to restore visual function after vision loss in the later stage of RP.
The open-label Phase 1/2a PIONEER study (ClinicalTrials.
Recently, in a blind patient, researchers combined intraocular injection of an adeno-associated virus vector encoding ChrimsonR with light stimulation through engineered goggles.
Comprehensive test of visual task and EEG recording
Comprehensive test of visual task and EEG recording Comprehensive test of visual task and EEG recordingWhen the patient wears the goggles, he can perceive, locate, count and touch different objects only with his vector-processed eyes.
When the patient wears the goggles, he can perceive, locate, count and touch different objects only with his vector-processed eyes.
Injection of adeno-associated virus vector encoding ChrimsonR and engineering goggles is indispensable for injection of adeno-associated virus vector encoding ChrimsonR and engineering goggles
In short, this is the first reported case of neurodegenerative disease partially restored function after optogenetic therapy .
Partial recovery of neurodegenerative diseases after optogenetic therapy.
Original source:
Original source:José-Alain Sahel et al.
José-Alain Sahel et al.
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