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    Home > Active Ingredient News > Endocrine System > Nat Med: Donor and recipient polygenic risk scores influence the risk of posttransplant diabetes

    Nat Med: Donor and recipient polygenic risk scores influence the risk of posttransplant diabetes

    • Last Update: 2022-05-11
    • Source: Internet
    • Author: User
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    Post-transplant diabetes mellitus (PTDM) reduces the lifespan of both the graft and recipient


    Post-transplant diabetes mellitus (PTDM) reduces the lifespan of both the graft and recipient


    Recently, a research article was published in the top medical journal Nature Medicine.


    We analyzed the association of PRS for PTDM and T2D in liver recipients (n=1581) and their donors (n=1555), and renal recipients (n=2062) and their donors (n=533)


    We analyzed the association of PRS for PTDM and T2D in liver recipients (n=1581) and their donors (n=1555), and renal recipients (n=2062) and their donors (n=533)


    The PRS model of T2D combined with liver donor and recipient significantly improved the predictive power of PTDM compared with the model including only clinical features: the area under the curve (AUC) for T2D combined with PRS was 67.


    The PRS model of T2D combined with liver donor and recipient significantly improved the predictive power of PTDM compared with the model including only clinical features: the area under the curve (AUC) for T2D combined with PRS was 67.


    Taken together, PRS for T2D can help identify patients at high risk for PTDM in transplant patients, for whom preventive diabetes treatment and donor selection may be necessary


    Original source:

    Abraham Shaked, et al.


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