529 (Omicron) variant of SARS-CoV-2 was first identified in South Africa in early November 2021, leading to an unprecedented global resurgence and widespread prevalence of coronavirus disease 2019 ( COVID-19 ) spread
Israeli authorities have approved the initiation of a fourth dose of the COVID-19 vaccine (ie, the second booster dose) for individuals aged 60 years and older who received the first booster dose four months or more after the last dose
Therefore, it is imperative to collect and collate evidence on the effectiveness of the second booster in reducing hospitalizations and mortality due to COVID-19
Recently, a research article was published in the top medical journal Nature Medicine.
This retrospective cohort study included all members of the Clalit Medical Service, who were between the ages of 60 and 100 and who were eligible by January 3, 2022.
Received a second booster shot of the vaccine
The researchers compared hospitalizations and mortality from COVID-19 in participants who received a second booster immunization
with those who received only one booster immunization .
In addition, we used Cox proportional hazards regression models with time-dependent covariates to estimate the association between a second booster immunization and hospitalizations and deaths from COVID-19, adjusting for demographic factors and comorbidities
A total of 563,465 participants in the study met study eligibility and criteria
Of these, 328,597 (58%) received a second booster vaccination during the 40-day study period
Hospitalization for COVID-19 occurred in 270 who received the second booster vaccine and 550 who received only one booster vaccine (adjusted hazard ratio, 0.
36; 95% confidence interval (CI), 0.
31 to 0.
Death from COVID-19 occurred in 92 participants who received the second booster vaccine and 232 who received only one booster vaccine (adjusted hazard ratio, 0.
22; 95% CI, 0.
17 to 0.
The study showed that among Israeli adults aged 60 years and older, hospitalizations and deaths due to Covid-19 were significantly reduced as a result of a second booster vaccine
Original source:Original source:
Ronen Arbel, et al.
Effectiveness of a second BNT162b2 booster vaccine against hospitalization and death from COVID-19 in adults aged over 60 years .
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