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    Home > Active Ingredient News > Infection > Nat Med: Malaria increases the risk of iron deficiency in African children

    Nat Med: Malaria increases the risk of iron deficiency in African children

    • Last Update: 2021-03-20
    • Source: Internet
    • Author: User
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    Malaria and iron deficiency (ID) are a major public health problem throughout Sub-Saharan Africa .
    They are very common among African children .
    The relationship between the two is complex and not yet fully understood.

    Malaria and iron deficiency (ID) are a major public health problem throughout Sub-Saharan Africa .
    They are very common among African children .
    The relationship between the two is complex and not yet fully understood.
    Malaria and iron deficiency (ID) are a major public health problem throughout Sub-Saharan Africa .
    They are very common among African children .
    The relationship between the two is complex and not yet fully understood.
    child

    ID may be caused by a variety of factors, including low-iron diets, dietary iron inhibitors such as polyferrophenols and phytic acid, and worm infections .
    Iron supplementation through tablets or syrup and micronutrient powder is the main intervention to control ID and anemia in children.

    infection


    However, in malaria-endemic countries, the safety and effectiveness of iron supplements have been questioned.


    In these countries, iron supplements may make individuals susceptible to malaria and other infections, so new management strategies are urgently needed .



    Sickle cell trait (HbAS) and iron deficiency prevention related

    prevention

    It is currently known that malaria can cause anemia through a variety of mechanisms, including the destruction of parasitic and non-parasitic red blood cells.


    This process will affect the concentration of hemoglobin, and the iron released by the damaged red blood cells will not be lost and can be recycled.



    In order to test the hypothesis that malaria may cause ID, the researchers used Mendelian randomization analysis, using sickle cell traits (HbAS, rs334) as an instrumental variable in Mendelian randomization analysis.


    This genetic mutation can confer specificity to malaria.



    Potential mechanism of iron deficiency caused by malaria

    Researchers found that among children in malaria-endemic countries in Africa, HbAS was associated with a 30% reduction in ID (n = 7,453), but there was no correlation in malaria-free areas (n = 3,818).
    Further research has shown that the genetically predicted risk of malaria is related to the ID odds ratio for each increase in the logarithmic incidence of malaria, which is 2.
    65.
    This shows that if the risk of malaria is reduced by half, the prevalence of ID among African children will be reduced by 49%.


    All in all, the results of the study show that malaria increases the risk of ID in African children.


    Researchers suggest that strategies to prevent and treat malaria and other infections should be part of controlling the incidence of iron deficiency in children in Africa.




    org/10.


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