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Obesity is closely related to a variety of metabolic diseases, including insulin resistance, type 2 diabetes , hypertension, dyslipidemia, and arteriosclerosis
.
Therefore, obesity is one of the main health challenges facing the world today
Obesity is closely related to a variety of metabolic diseases, including insulin resistance, type 2 diabetes , hypertension, dyslipidemia, and arteriosclerosis
Many cell types in the human body use endoreplication as a means to adapt to the massive increase in volume
.
In the process of internal replication, fully differentiated cells re-enter the cell cycle and synthesize DNA, but do not divide, resulting in an increase in the DNA content of large cells and an increase in nuclear size and/or number of nuclei
Many cell types in the human body use endoreplication as a means to adapt to the massive increase in volume
In addition to its role in lipid storage, fat cells are also secretors of adipokines, which have a wide range of effects on the function of the entire body
Cell cycle transcription profile expressed by mature human adipocytes
.
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Cell cycle transcription profile expressed by mature human adipocytes
Recently, researchers have demonstrated that mature human adipocytes, although long believed to be cells after mitosis, unexpectedly display a genetic and protein signature that can activate cell cycle programs related to obesity and hyperinsulinemia, and This is accompanied by an increase in cell and nucleus size
The cell cycle progression of adipocytes is related to obesity and hyperinsulinemia .
Premature aging is quickly becoming an important mediator of the recognized stress-induced tissue dysfunction
The researchers further showed that by using metformin to target the cell cycle program of adipocytes, it is possible to affect the aging of adipocytes and obesity-related adipose tissue inflammation
Original source:
Original source: Original source:Qian Li al.
Qian Li al.
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