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The gut microbiome has becomeTumor extrinsic predictive biomarkers of immune
immunity
In the study, researchers evaluated a new melanoma cohort, as well as four published datasets
Bioinformatics
Time-event analysis showed that baseline microbiota composition was best associated with clinical outcomes approximately 1 year after treatment initiation
Lachnospiraceae Streptococcus
Figure Compositional differences in the fecal microbiome of anti-PD-1-treated melanoma patients are associated with differential progression-free survival
Figure Compositional differences in the fecal microbiome of anti-PD-1-treated melanoma patients are associated with differential progression-free survivalTaken together, our findings reveal a complex interplay between the gut microbiome and cancer immunotherapy response, providing directions for future research
references:
references:McCulloch, JA, Davar, D.
McCulloch, JA, Davar, D.
, Rodrigues, RRet al.
Intestinal microbiota signatures of clinical response and immune-related adverse events in melanoma patients treated with anti-PD-1.
Nat Med28,545–556 (2022).
https ://doi.
org/10.
1038/s41591-022-01698-2 et al.
Nat Med 28,
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