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Adoptive cell therapy using tumor infiltrating lymphocytes (TIL) has been shown to be useful for the treatment of melanoma, but this therapy has not been previously evaluated in metastatic non-small cell lung cancer
.
Recently, the top medical journal Nature Medicine published a research article.
Researchers conducted a single-group open-label phase 1 trial (NCT03215810) in 20 patients with advanced non-small cell lung cancer who received nivolumab monotherapy.
)
.
The primary endpoint of the study is safety, and secondary endpoints include objective response rate, duration of response, and T cell persistence
.
Autologous TIL is amplified in vitro from minced tumors cultured with interleukin-2
.
The patient received cyclophosphamide and fludarabine, TIL infusion, and interleukin-2 treatment, followed by nivolumab maintenance therapy
.
Adverse events arising from treatment
Of the 13 patients evaluated, 3 patients have confirmed remission, 11 patients have reduced tumor burden, and the median best change is 35%
.
Two patients achieved sustained complete remission after 1.
5 years
It can be seen that autologous TIL cell therapy is generally safe and clinically active, and may be used as a new treatment for patients with metastatic lung cancer
.
.
Original source:
Original source:Benjamin C.
Creelan,et al.
Tumor-infiltrating lymphocyte treatment for anti- PD-1-resistant metastatic lung cancer: a phase 1 trial in this message